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01-12-2015 | Original Article

Knowledge and attitudes of Brazilian dental students and dentists regarding bisphosphonate-related osteonecrosis of the jaw

Authors: Paula Baptistella de Lima, Veruska Lima Moura Brasil, Jurema Freire Lisboa de Castro, Flávia Maria de Moraes Ramos-Perez, Fábio Abreu Alves, Maria Luiza dos Anjos Pontual, Danyel Elias da Cruz Perez

Published in: Supportive Care in Cancer | Issue 12/2015

Abstract

Purpose

The aim of this study was to evaluate the knowledge of Brazilian dentists (DEN) and dental students (DS) about bisphosphonates (BP) and bisphosphonate-related osteonecrosis of the jaw (BRONJ).

Methods

A convenience sample of 104 DEN and 100 DS was randomly selected and invited to answer a questionnaire. The questionnaire was structured on the basis of the main information about BP and the risk factors associated with the development of BRONJ. The data obtained were analyzed by the chi-square and Fisher’s exact tests, considering significance of 5 %.

Results

Seventy-five (72.1 %) DEN and 75 (75 %) DS did not know the BP cited in the questionnaire (p < 0.0001), and their commercial brand names were not recognized by 88 (84.6 %) DEN and 86 (86 %) DS (p < 0.0001). In the same way, 62 (59.6 %) DEN (p = 0.04) and 58 (58 %) DS (p < 0.0001) did not recognize BRONJ as an oral side effect of BP or point out oral conditions that were not associated with the use of BP.

Conclusions

Practical initiatives, such as free lectures and workshops, must be taken to broaden the knowledge of DEN and DS about BP and thus contribute to the prevention of BRONJ.

Coleman RE (2008) Risks and benefits of bisphosphonates. Br J Cancer 98:1736–1740PubMedCentralCrossRefPubMed

Hess LM, Jeter JM, Benham-Hutchins M, Alberts DS (2009) Factors associated with osteonecrosis of the jaw among bisphosphonate users. Am J Med 121:475–483CrossRef

Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B (2009) American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws—2009 update. J Oral Maxillofac Surg 67:2–12CrossRefPubMed

Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O’Ryan F, American Association of Oral and Maxillofacial Surgeons (2014) American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw—2014 update. J Oral Maxillofac Surg 72:1938–1956CrossRefPubMed

Pires FR, Miranda A, Cardoso ES, Cardoso AS, Fregnani ER, Pereira CM, Correa ME, Almeida JP, Alves Fde A, Lopes MA, de Almeida OP (2005) Oral avascular bone necrosis associated with chemotherapy and biphosphonate therapy. Oral Dis 11:365–369CrossRefPubMed

Mercer E, Norton T, Woo S, Treister N, Dodson TB, Solomon DH (2013) Ninety-one osteoporosis patients affected with bisphosphonate-related osteonecrosis of the jaw: a case series. Calcif Tissue Int 93:241–248PubMedCentralCrossRefPubMed

Otto S, Schreyer C, Hafner S, Mast G, Ehrenfeld M, Stürzenbaum S, Pautke C (2012) Bisphosphonate-related osteonecrosis of the jaws—characteristics, risk factors, clinical features, localization and impact on oncological treatment. J Craniomaxillofac Surg 40:303–309CrossRefPubMed

Lazarovici TS, Yahalom R, Taicher S, Elad S, Hardan I, Yarom N (2009) Bisphosphonate-related osteonecrosis of the jaws: a single-center study of 101 patients. J Oral Maxillofac Surg 67:850–855CrossRefPubMed

Nicolatou-Galitis O, Papadopoulou E, Sarri T, Boziari P, Karayianni A, Kyrtsonis MC, Repousis P, Barbounis V, Migliorati CA (2011) Osteonecrosis of the jaw in oncology patients treated with bisphosphonates: prospective experience of a dental oncology referral center. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:195–202CrossRefPubMed

10.

Hallmer F, Bjørnland T, Nicklasson A, Becktor JP, Andersson G (2014) Osteonecrosis of the jaw in patients treated with oral and intravenous bisphosphonates: experience in Sweden. Oral Surg Oral Med Oral Pathol Oral Radiol 118:202–208CrossRefPubMed

11.

Vandone AM, Donadio M, Mozzati M, Ardine M, Polimeni MA, Beatrice S, Ciuffreda L, Scoletta M (2012) Impact of dental care in the prevention of bisphosphonate-associated osteonecrosis of the jaw: a single-center clinical experience. Ann Oncol 23:193–200CrossRefPubMed

12.

López-Jornet P, Camacho-Alonso F, Molina-Miñano F, Gomez-Garcia F (2010) Bisphosphonate-associated osteonecrosis of the jaw. Knowledge and attitudes of dentists and dental students: a preliminary study. J Eval Clin Pract 16:878–882CrossRefPubMed

13.

Abu-id MH, Warnke PH, Gottschalk J, Springer I, Wiltfang J, Acil Y, Russo PA, Kreusch T (2008) “Bis-phossy jaws”—high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. J Craniomaxillofac Surg 36:95–103CrossRefPubMed

14.

Bauer JS, Beck N, Kiefer J, Stockmann P, Wichmann M, Eitner S (2012) Awareness and education of patients receiving bisphosphonates. J Craniomaxillofac Surg 40:277–282CrossRefPubMed

15.

Wood J, Bonjean K, Ruetz S, Bellahcène A, Devy L, Foidart JM, Castronovo V, Green JR (2002) Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 302:1055–1061CrossRefPubMed

16.

de Souza Faloni AP, Queiroz TP, Comelli Lia RC, Cerri PS, Margonar R, Rastelli AN, Marcantonio E (2011) Accurate approach in the treatment of oral bisphosphonate-related jaw osteonecrosis. J Craniofac Surg 22:2185–2190CrossRefPubMed

17.

Migliorati CA, Mattos K, Palazzolo MJ (2010) How patients’ lack of knowledge about oral bisphosphonates can interfere with medical and dental care. J Am Dent Assoc 141:562–566CrossRefPubMed

18.

Saad F, Brown JE, Van Poznak C, Ibrahim T, Stemmer SM, Stopeck AT, Diel IJ, Takahashi S, Shore N, Henry DH, Barrios CH, Facon T, Senecal F, Fizazi K, Zhou L, Daniels A, Carrière P, Dansey R (2012) Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Ann Oncol 23:1341–1347CrossRefPubMed

19.

Dhima M, Petropoulos VC, Han RK, Kinnunen T, Wright RF (2012) Dental students' perceptions of dental specialties and factors influencing specialty and career choices. J Dent Educ 76:562–573PubMed

20.

Epstein JB, Kish RV, Hallajian L, Sciubba J (2015) Head and neck, oral and oropharyngeal cancer: a review of medicolegal cases. Oral Surg Oral Med Oral Pathol Oral Radiol 119:177–186CrossRefPubMed

Title: Knowledge and attitudes of Brazilian dental students and dentists regarding bisphosphonate-related osteonecrosis of the jaw
Authors: Paula Baptistella de Lima
Veruska Lima Moura Brasil
Jurema Freire Lisboa de Castro
Flávia Maria de Moraes Ramos-Perez
Fábio Abreu Alves
Maria Luiza dos Anjos Pontual
Danyel Elias da Cruz Perez
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 12/2015
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-015-2689-6

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