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Supportive Care in Cancer

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01-12-2012 | Original Article

Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy

Authors: Chueh-Lung Hwang, Chong-Jen Yu, Jin-Yuan Shih, Pan-Chyr Yang, Ying-Tai Wu

Published in: Supportive Care in Cancer | Issue 12/2012

Abstract

Purpose

Peak oxygen consumption (VO_2peak) is an important predictive factor for long-term prognosis in patients with non-small cell lung cancer (NSCLC). The purpose of this study was to investigate whether 8 weeks of exercise training improves exercise capacity, as assessed by VO_2peak, and other related factors in patients with NSCLC receiving targeted therapy.

Methods

A total of 24 participants with adenocarcinoma were randomly assigned to either the control group (n = 11) or the exercise group (n = 13). Subjects in the exercise group participated in individualized, high-intensity aerobic interval training of exercise. The outcome measures assessed at baseline and after 8 weeks were as follows: VO_2peak and the percentage of predicted VO_2peak (%predVO_2peak), muscle strength and endurance of the right quadriceps, muscle oxygenation during exercise, insulin resistance as calculated by the homeostasis model, high-sensitivity C-reactive protein, and quality of life (QoL) questionnaire inventory.

Results

No exercise-related adverse events were reported. After exercise training, VO_2peak and %predVO_2peak increased by 1.6 mL kg⁻¹ min⁻¹ and 5.3% (p < 0.005), respectively; these changes were associated with improvements in circulatory, respiratory, and muscular functions at peak exercise (all p = 0.001). The exercise group also had less dyspnea (p = 0.01) and favorably lower fatigue (p = 0.05) than baseline.

Conclusions

Patients with NSCLC receiving targeted therapy have quite a low exercise capacity, even with a relatively high QoL. Exercise training appears to improve exercise capacity and alleviate some cancer-related symptoms.

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Title: Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy
Authors: Chueh-Lung Hwang
Chong-Jen Yu
Jin-Yuan Shih
Pan-Chyr Yang
Ying-Tai Wu
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Supportive Care in Cancer / Issue 12/2012
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-012-1452-5

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