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01-02-2011 | Original Article

Standardized phase angle from bioelectrical impedance analysis as prognostic factor for survival in patients with cancer

Authors: Silvana Iturriet Paiva, Lúcia R. Borges, Denise Halpern-Silveira, M. Cecília F. Assunção, Aluisio J. D. Barros, M. Cristina Gonzalez

Published in: Supportive Care in Cancer | Issue 2/2011

Abstract

Purpose

Phase angle (PA), determined by bioelectrical impedance analysis (BIA), has been considered as a prognostic factor in several clinical conditions. The purpose of this study is to investigate PA, after adjusting for sex and age (standardized phase angle; SPA) as a prognostic factor for survival in cancer patients.

Methods

A prospective study was conducted in 195 patients before the first chemotherapy course. BIA was performed in all patients and SPA was calculated. The Kaplan-Meier method was used to calculate survival. The Cox regression method was used to evaluate the independent prognostic effect of PA after adjustment for other variables.

Results

Patients with SPA < −1.65 had a smaller survival rate than those with SPA ≥ −1.65 (p < 0.001). Using Cox regression, the mortality rate was higher in patients with SPA < −1.65 (RR 3.12 CI: 2.03–4.79; p < 0.001). After multivariate analysis, patients with PA < −1.65 still presented a higher mortality rate (RR 2.35 CI: 1.41–3.90; p = 0.001).

Conclusions

The present study demonstrates that PA, used as SPA, is an independent prognostic indicator in this group of cancer patients receiving chemotherapy treatment even after adjustment for other prognostic variables.

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Title: Standardized phase angle from bioelectrical impedance analysis as prognostic factor for survival in patients with cancer
Authors: Silvana Iturriet Paiva
Lúcia R. Borges
Denise Halpern-Silveira
M. Cecília F. Assunção
Aluisio J. D. Barros
M. Cristina Gonzalez
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: Supportive Care in Cancer / Issue 2/2011
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-009-0798-9

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Abstract

Purpose

Methods

Results

Conclusions

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