Skip to main content
Top
Published in: Supportive Care in Cancer 11/2009

01-11-2009 | Review Article

A descriptive review of the factors contributing to nutritional compromise in patients with head and neck cancer

Authors: Martin R. Chasen, Ravi Bhargava

Published in: Supportive Care in Cancer | Issue 11/2009

Login to get access

Abstract

Introduction

Malnutrition has been known to be associated with adverse outcomes in cancer patients. Patients who have been and/or are being treated for head and neck cancer have a compromised nutritional status. Nutritional deficits have a significant impact on mortality, morbidity, and quality of life.

Discussion

The wasting in cancer cachexia involves loss of muscle and fat and reflects a catabolic metabolism induced by an abnormal host response to tumor presence and/or tumor factors. Disturbances of various physiological functions like taste, smell, dysphagia, xerostomia apart from cachexia can contribute to long-term nutritional complications and outcome.

Conclusion

Improved management of patients in posttreatment for head and neck cancer may require a multimodal approach by a multidisciplinary team and is best commenced earlier in the trajectory of the disease.
Literature
1.
go back to reference Hammerlid E, Wirblad B, Sandin C et al (1998) Malnutrition and food intake in relation to quality of life in head and neck cancer patients. Head Neck 20:540–548CrossRefPubMed Hammerlid E, Wirblad B, Sandin C et al (1998) Malnutrition and food intake in relation to quality of life in head and neck cancer patients. Head Neck 20:540–548CrossRefPubMed
2.
go back to reference van Marian AE, van der Schueren Bokhorst-de, van Paul AM, Leeuwen DJ, Kuik WM, Klop C, Sauerwein HP, Snow GB, Quak JJ (1999) The impact of nutritional status on the prognoses of patients with advanced head and neck cancer. Cancer 86(3):519–527CrossRef van Marian AE, van der Schueren Bokhorst-de, van Paul AM, Leeuwen DJ, Kuik WM, Klop C, Sauerwein HP, Snow GB, Quak JJ (1999) The impact of nutritional status on the prognoses of patients with advanced head and neck cancer. Cancer 86(3):519–527CrossRef
3.
go back to reference Hussey DH, Latourette HB, Panje WR (1991) Head and neck cancer: an analysis of the incidence, patterns of treatment, and survival at the University of Iowa. Ann Otol Rhinol Laryngol Suppl 152:2–16PubMed Hussey DH, Latourette HB, Panje WR (1991) Head and neck cancer: an analysis of the incidence, patterns of treatment, and survival at the University of Iowa. Ann Otol Rhinol Laryngol Suppl 152:2–16PubMed
5.
go back to reference Tisdale MJ (1997) Cancer cachexia metabolic alterations and clinical manifestations. Nutrition 13:1–7CrossRefPubMed Tisdale MJ (1997) Cancer cachexia metabolic alterations and clinical manifestations. Nutrition 13:1–7CrossRefPubMed
6.
go back to reference Westin T, Jansson A, Zenckert C, Hallstro MT, Edstro MS (1988) Mental depression is associated with malnutrition in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 114:1449–1453PubMed Westin T, Jansson A, Zenckert C, Hallstro MT, Edstro MS (1988) Mental depression is associated with malnutrition in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 114:1449–1453PubMed
7.
go back to reference Brookes GB (1985) Nutritional status—a prognostic indicator in head and neck cancer. Otolaryngol Head Neck Surg 93:69–74PubMed Brookes GB (1985) Nutritional status—a prognostic indicator in head and neck cancer. Otolaryngol Head Neck Surg 93:69–74PubMed
9.
go back to reference Wu CH, Hsiao TY, Ko JY, Hsu MM (2000) Dysphagia after radiation: endoscopic examination of swallowing in patients with nasopharyngeal carcinoma. Ann Otol Rhinol Laryngol 109:320–325PubMed Wu CH, Hsiao TY, Ko JY, Hsu MM (2000) Dysphagia after radiation: endoscopic examination of swallowing in patients with nasopharyngeal carcinoma. Ann Otol Rhinol Laryngol 109:320–325PubMed
10.
go back to reference Ward EC, Bishop B, Frisby J, Stevens M (2002) Swallowing outcomes following laryngectomy and pharyngolaryngectomy. Arch Otolaryngol Head Neck Surg 128:181–186PubMed Ward EC, Bishop B, Frisby J, Stevens M (2002) Swallowing outcomes following laryngectomy and pharyngolaryngectomy. Arch Otolaryngol Head Neck Surg 128:181–186PubMed
11.
go back to reference Abendstein H, Nordgren M, Boysen M (2005) Quality of life and head and neck cancer: a 5 year prospective study. Laryngoscope. 115:2183–2192CrossRefPubMed Abendstein H, Nordgren M, Boysen M (2005) Quality of life and head and neck cancer: a 5 year prospective study. Laryngoscope. 115:2183–2192CrossRefPubMed
12.
go back to reference Van Bokhorst-de Van der Schueren MA, Langendoen SI, Vondeling H et al (2000) Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients: a randomized clinical trial. Clin Nutr 19:437–444. doi:10.1054/clnu.2000.0148 CrossRef Van Bokhorst-de Van der Schueren MA, Langendoen SI, Vondeling H et al (2000) Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients: a randomized clinical trial. Clin Nutr 19:437–444. doi:10.​1054/​clnu.​2000.​0148 CrossRef
14.
go back to reference Kiesow F (1894) Beitra¨ge zur physiologischen Psychologie des geschmackssinnes. Wundts Philos Stud 10:329–368 Kiesow F (1894) Beitra¨ge zur physiologischen Psychologie des geschmackssinnes. Wundts Philos Stud 10:329–368
16.
go back to reference Duffy V, Lucchina L, Fast K, Bartoshuk L (1998) Taste and cancer. In: Berger A (ed) Principles and practice of supportive oncology. Lippincott-Raven, Philadelphia, pp 141–151 Duffy V, Lucchina L, Fast K, Bartoshuk L (1998) Taste and cancer. In: Berger A (ed) Principles and practice of supportive oncology. Lippincott-Raven, Philadelphia, pp 141–151
17.
go back to reference Kitagoh H, Tomita H (1995) Healing process of taste receptor disturbance. Nippon Jibiinkoka Gakkai Kaiho 98:267–280 (Japanese)PubMed Kitagoh H, Tomita H (1995) Healing process of taste receptor disturbance. Nippon Jibiinkoka Gakkai Kaiho 98:267–280 (Japanese)PubMed
18.
go back to reference Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn-Tucker E, Potter C, Blendowski C (1999) Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum 26:697–706PubMed Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn-Tucker E, Potter C, Blendowski C (1999) Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum 26:697–706PubMed
20.
go back to reference Fernando IN, Pate T, Billingham L, Hammond C, Hallmark S, Glaholm J, Henk J (1995) The effect of head and neck irradiation on taste dysfunction: a prospective study. Clinical Oncology 7(3):173–178CrossRefPubMed Fernando IN, Pate T, Billingham L, Hammond C, Hallmark S, Glaholm J, Henk J (1995) The effect of head and neck irradiation on taste dysfunction: a prospective study. Clinical Oncology 7(3):173–178CrossRefPubMed
21.
go back to reference Magne N, Marcy PY, Foa C et al (2001) Comparison between nasogastric tube feeding and percutaneous endoscopic gastrostomy in advanced head and neck cancer patients. Eur Arch Otorhinolaryngol 258:89–92. doi:10.1007/s004050000311 CrossRefPubMed Magne N, Marcy PY, Foa C et al (2001) Comparison between nasogastric tube feeding and percutaneous endoscopic gastrostomy in advanced head and neck cancer patients. Eur Arch Otorhinolaryngol 258:89–92. doi:10.​1007/​s004050000311 CrossRefPubMed
22.
go back to reference Bonanni G, Perazzi F (1965) Behavior of taste sensitivity in patients subjected to high energy radiologic treatment for tumors of the oral cavity. Nunt Radiol 31:383–397PubMed Bonanni G, Perazzi F (1965) Behavior of taste sensitivity in patients subjected to high energy radiologic treatment for tumors of the oral cavity. Nunt Radiol 31:383–397PubMed
23.
go back to reference Tanikawa K (1963) Clinical and experimental studies on radiation injury to taste. Nippon Acta Radiol 23:704–712PubMed Tanikawa K (1963) Clinical and experimental studies on radiation injury to taste. Nippon Acta Radiol 23:704–712PubMed
24.
go back to reference Schwartz LK, Weiffenbach JM, Valdez IH, Fox PC (1993) Taste intensity performance in patients irradiated to the head and neck. Physiol Behav 53(4):671–677CrossRefPubMed Schwartz LK, Weiffenbach JM, Valdez IH, Fox PC (1993) Taste intensity performance in patients irradiated to the head and neck. Physiol Behav 53(4):671–677CrossRefPubMed
25.
go back to reference Mossman KL, Henkin RI (1978) Radiation-induced changes in taste acuity in cancer patients. Int J Radiat Oncol Biol Phys 4:663–670PubMed Mossman KL, Henkin RI (1978) Radiation-induced changes in taste acuity in cancer patients. Int J Radiat Oncol Biol Phys 4:663–670PubMed
26.
go back to reference Mossman KL, Chencharick JD, Scheer AC et al (1979) Radiation induced changes in gustatory function: comparison of effects of neutron and photon irradiation. Int J Radiat Oncol Biol Phys 5:521–528PubMed Mossman KL, Chencharick JD, Scheer AC et al (1979) Radiation induced changes in gustatory function: comparison of effects of neutron and photon irradiation. Int J Radiat Oncol Biol Phys 5:521–528PubMed
27.
go back to reference Mossman K, Shatzman A, Chencharick J (1982) Long-term effects of radiotherapy on taste and salivary function in man. Int J Radiat Oncol Biol Phys 8:991–997PubMed Mossman K, Shatzman A, Chencharick J (1982) Long-term effects of radiotherapy on taste and salivary function in man. Int J Radiat Oncol Biol Phys 8:991–997PubMed
28.
go back to reference Bartoshuk LM (1990) Chemosensory alterations and cancer therapies. NCI Monogr 9:179–184PubMed Bartoshuk LM (1990) Chemosensory alterations and cancer therapies. NCI Monogr 9:179–184PubMed
31.
go back to reference Mandel ID (1987) The functions of saliva. J Dent Res 66(Spec no):623–627PubMed Mandel ID (1987) The functions of saliva. J Dent Res 66(Spec no):623–627PubMed
32.
go back to reference Cooper JS, Fu K, Marks J, Silverman S (1995) Late effects of radiation therapy in the head and neck region. Int J Radiat Oncol Biol Phys 31:1141–1164PubMed Cooper JS, Fu K, Marks J, Silverman S (1995) Late effects of radiation therapy in the head and neck region. Int J Radiat Oncol Biol Phys 31:1141–1164PubMed
34.
go back to reference Brizel DM, Wasserman TH, Henke M et al (2000) Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol 18:3339–3345PubMed Brizel DM, Wasserman TH, Henke M et al (2000) Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol 18:3339–3345PubMed
37.
go back to reference Machtay M, Rosenthal DI, Hershock D et al (2002) Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania Phase II Trial. J Clin Oncol 20:3964–3971. doi:10.1200/JCO.2002.11.026 CrossRefPubMed Machtay M, Rosenthal DI, Hershock D et al (2002) Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania Phase II Trial. J Clin Oncol 20:3964–3971. doi:10.​1200/​JCO.​2002.​11.​026 CrossRefPubMed
39.
go back to reference Logemann JA, Pauloski BR, Rademaker AW et al (2003) Xerostomia: 12-month changes in saliva production and its relationship to perception and performance of swallow function, oral intake, and diet after chemoradiation. Head Neck 25:432–437. doi:10.1002/hed.10255 CrossRefPubMed Logemann JA, Pauloski BR, Rademaker AW et al (2003) Xerostomia: 12-month changes in saliva production and its relationship to perception and performance of swallow function, oral intake, and diet after chemoradiation. Head Neck 25:432–437. doi:10.​1002/​hed.​10255 CrossRefPubMed
40.
go back to reference Bhattacharyya N (2002) Factors predicting survival for cancer of the ethmoid sinus. Am J Rhinol 16(5):281–286PubMed Bhattacharyya N (2002) Factors predicting survival for cancer of the ethmoid sinus. Am J Rhinol 16(5):281–286PubMed
42.
go back to reference Mekhail TM, Adelstein DJ, Rybicki LA, Larto MA, Saxton JP, Lavertu P (2001) Enteral nutrition during the treatment of head and neck carcinoma. Cancer 91:1785–1790CrossRefPubMed Mekhail TM, Adelstein DJ, Rybicki LA, Larto MA, Saxton JP, Lavertu P (2001) Enteral nutrition during the treatment of head and neck carcinoma. Cancer 91:1785–1790CrossRefPubMed
43.
go back to reference Laurell G, Kraepelien T, Mavroidis P et al (2003) Stricture of the proximal esophagus in head and neck carcinoma patients after radiotherapy. Cancer 97:1693–1700CrossRefPubMed Laurell G, Kraepelien T, Mavroidis P et al (2003) Stricture of the proximal esophagus in head and neck carcinoma patients after radiotherapy. Cancer 97:1693–1700CrossRefPubMed
44.
go back to reference Maguire PD, Meyerson MB, Neal CR et al (2004) Toxic cure: hyperfractionated radiotherapy with concurrent cisplatin and fluorouracil for stage III, and IVA head-and neck cancer in the community. Int J Radiat Oncol Biol Physiol 58:698–704CrossRef Maguire PD, Meyerson MB, Neal CR et al (2004) Toxic cure: hyperfractionated radiotherapy with concurrent cisplatin and fluorouracil for stage III, and IVA head-and neck cancer in the community. Int J Radiat Oncol Biol Physiol 58:698–704CrossRef
47.
48.
go back to reference Giacosa A, Frascio F, Sukkar SG, Roncella S (1995) Cytokines and nutritional response in cancer cachexia. Paper presented at the National Institute for Cancer Research, Genoa, Italy Giacosa A, Frascio F, Sukkar SG, Roncella S (1995) Cytokines and nutritional response in cancer cachexia. Paper presented at the National Institute for Cancer Research, Genoa, Italy
49.
go back to reference Bruera E, Carraro S, Roca E, Cedaro L, Chacon R (1984) Association between malnutrition and caloric intake, emesis, psychological depression, glucose taste and tumour mass. Cancer Treat Rep 68:873PubMed Bruera E, Carraro S, Roca E, Cedaro L, Chacon R (1984) Association between malnutrition and caloric intake, emesis, psychological depression, glucose taste and tumour mass. Cancer Treat Rep 68:873PubMed
50.
go back to reference Evans WK, Nixon DW, Daly JM et al (1987) A randomized study of oral nutritional support versus ad lib nutritional intake during chemotherapy for advanced colorectal and non-small-cell lung cancer. J Clin Oncol 5:113PubMed Evans WK, Nixon DW, Daly JM et al (1987) A randomized study of oral nutritional support versus ad lib nutritional intake during chemotherapy for advanced colorectal and non-small-cell lung cancer. J Clin Oncol 5:113PubMed
51.
go back to reference Ovesen L, Allingstrup L, Hannibal EL, Hansen OP (1993) Effect of dietary counselling on food intake, body weight, response rate, survival and quality of life in cancer patients undergoing chemotherapy: a prospective, randomized study. J Clin Oncol 11:2043PubMed Ovesen L, Allingstrup L, Hannibal EL, Hansen OP (1993) Effect of dietary counselling on food intake, body weight, response rate, survival and quality of life in cancer patients undergoing chemotherapy: a prospective, randomized study. J Clin Oncol 11:2043PubMed
52.
go back to reference Strasser F (2003) Eating-related disorders in patients with advanced cancer. Support Care Cancer 11:11–20PubMed Strasser F (2003) Eating-related disorders in patients with advanced cancer. Support Care Cancer 11:11–20PubMed
53.
go back to reference Brookes GB (1985) Nutritional status: a prognostic indicator in head and neck cancer. Otolaryngol Head Neck Surg 93:69–74PubMed Brookes GB (1985) Nutritional status: a prognostic indicator in head and neck cancer. Otolaryngol Head Neck Surg 93:69–74PubMed
54.
go back to reference Reilly JJ (1990) Does nutrition management benefit the head and neck cancer patient? Oncology 4:105–115PubMed Reilly JJ (1990) Does nutrition management benefit the head and neck cancer patient? Oncology 4:105–115PubMed
55.
go back to reference D’Antonio lL, Zimmermen GJ, Cella DF, Long SA (1996) Quality of life and functional status measures in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 122:482–487PubMed D’Antonio lL, Zimmermen GJ, Cella DF, Long SA (1996) Quality of life and functional status measures in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 122:482–487PubMed
56.
go back to reference Devins GM, Stam HJ, Koopmans JP (1994) Psychosocial impact of laryngectomy mediated by perceived stigma and illness intrusiveness. Can J Psychiatry 39:608–616PubMed Devins GM, Stam HJ, Koopmans JP (1994) Psychosocial impact of laryngectomy mediated by perceived stigma and illness intrusiveness. Can J Psychiatry 39:608–616PubMed
57.
59.
go back to reference MacDonald N (2005) Anorexia–cachexia syndrome. Eur J Palliat Care 12(2 Suppl):8–15 MacDonald N (2005) Anorexia–cachexia syndrome. Eur J Palliat Care 12(2 Suppl):8–15
60.
go back to reference Nicholas PK, Leuner JD, Hatfield JM et al (2006) Using the Cancer Rehabilitation Questionnaire in patients with colorectal cancer. Rehabil Nurs 31:106–113PubMed Nicholas PK, Leuner JD, Hatfield JM et al (2006) Using the Cancer Rehabilitation Questionnaire in patients with colorectal cancer. Rehabil Nurs 31:106–113PubMed
62.
go back to reference Bond MR (1979) Psychological and emotional aspects of cancer pain. In: Bonica JJ, Ventafredda V (eds) Advances in pain research and therapy. International Symposium on Pain of Advanced Cancer, vol 2. Raven Press, New York, pp 81–88 Bond MR (1979) Psychological and emotional aspects of cancer pain. In: Bonica JJ, Ventafredda V (eds) Advances in pain research and therapy. International Symposium on Pain of Advanced Cancer, vol 2. Raven Press, New York, pp 81–88
63.
go back to reference Westin T, Jannsson A, Zenckert C, Hallstrom T, Edstrom S (1988) Mental depression is associated with malnutrition in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 114:1449–1453PubMed Westin T, Jannsson A, Zenckert C, Hallstrom T, Edstrom S (1988) Mental depression is associated with malnutrition in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 114:1449–1453PubMed
64.
go back to reference Bukberg J, Penman D, Holland JC (1984) Depression in hospitalized cancer patients. Psychosom Med 46:199–212PubMed Bukberg J, Penman D, Holland JC (1984) Depression in hospitalized cancer patients. Psychosom Med 46:199–212PubMed
66.
go back to reference Farberow NL, Ganzler S, Cutter F, Reynolds D (1971) An eight-year survey of hospital suicides. Life-Threat Beha 6(1):184–201 Farberow NL, Ganzler S, Cutter F, Reynolds D (1971) An eight-year survey of hospital suicides. Life-Threat Beha 6(1):184–201
67.
go back to reference Saunders JR, Brown MS, Hirata RM, Jaques DA (1991) Percutaneous endoscopic gastrostomy in patients with head and neck malignancies. Am J Surg 162:381–3CrossRefPubMed Saunders JR, Brown MS, Hirata RM, Jaques DA (1991) Percutaneous endoscopic gastrostomy in patients with head and neck malignancies. Am J Surg 162:381–3CrossRefPubMed
68.
go back to reference Larson DE, Burton DD, Schroeder KW, Di Mango EP (1987) Percutaneous endoscopic gastrostomy: indications, success, complications, and mortality in 314 consecutive patients. Gastroenterology 93:48–52PubMed Larson DE, Burton DD, Schroeder KW, Di Mango EP (1987) Percutaneous endoscopic gastrostomy: indications, success, complications, and mortality in 314 consecutive patients. Gastroenterology 93:48–52PubMed
69.
go back to reference Shike M, Berner YN, Gerdes H et al (1989) Percutaneous endoscopic gastrostomy and jejunostomy for long term enteral feeding in patients with cancer of the head and neck. Otolaryngol Head Neck Surg 101:549–554PubMed Shike M, Berner YN, Gerdes H et al (1989) Percutaneous endoscopic gastrostomy and jejunostomy for long term enteral feeding in patients with cancer of the head and neck. Otolaryngol Head Neck Surg 101:549–554PubMed
70.
go back to reference Scott JS, de la Torre RA, Unger SW (1991) Comparison of operative versus percutaneous endoscopic gastrostomy tube placement in the elderly. Am Surg 57:338–340PubMed Scott JS, de la Torre RA, Unger SW (1991) Comparison of operative versus percutaneous endoscopic gastrostomy tube placement in the elderly. Am Surg 57:338–340PubMed
71.
go back to reference Stern JS (1986) Comparison of percutaneous endoscopic gastrostomy with surgical gastrostomy at a community hospital. Am J Gastroenterol 81:1171–1173PubMed Stern JS (1986) Comparison of percutaneous endoscopic gastrostomy with surgical gastrostomy at a community hospital. Am J Gastroenterol 81:1171–1173PubMed
72.
74.
go back to reference Dietz A, Nollert J, Maier H, Rudat V, Fientje M (1995) The problem of radiotherapy or chemotherapy induced mucositis of the mouth and pharynx. Effects of accelerated chemoradiation with carboplatinum on patients with inoperable squamous cell carcinoma of the head and neck. Experiences in Heidelberg. HNO 43:403–413PubMed Dietz A, Nollert J, Maier H, Rudat V, Fientje M (1995) The problem of radiotherapy or chemotherapy induced mucositis of the mouth and pharynx. Effects of accelerated chemoradiation with carboplatinum on patients with inoperable squamous cell carcinoma of the head and neck. Experiences in Heidelberg. HNO 43:403–413PubMed
75.
go back to reference Bosaeus I, Daneryd P, Svanberg E, Lundholm K (2001) Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int J Cancer 93:380–383CrossRefPubMed Bosaeus I, Daneryd P, Svanberg E, Lundholm K (2001) Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. Int J Cancer 93:380–383CrossRefPubMed
76.
go back to reference Piquet MA, Ozsahin M, Larpin I, Zouhair A, Coti P et al (2002) Early nutritional intervention in oropharyngeal cancer patients undergoing radiotherapy. Support Care Cancer 10:502–504CrossRefPubMed Piquet MA, Ozsahin M, Larpin I, Zouhair A, Coti P et al (2002) Early nutritional intervention in oropharyngeal cancer patients undergoing radiotherapy. Support Care Cancer 10:502–504CrossRefPubMed
79.
81.
go back to reference Howard L, Patton L (1998) Outcome of long-term enteral feeding. Gastrointest Endosc Clin N Am 8:705–723PubMed Howard L, Patton L (1998) Outcome of long-term enteral feeding. Gastrointest Endosc Clin N Am 8:705–723PubMed
83.
go back to reference Scolapio JS, Spangler PR, Romano, Michelle M, McLaughlin MP, Salassa JR (2001) Prophylactic placement of gastrostomy feeding tubes before radiotherapy in patients with head and neck cancer: Is it worthwhile?. J Clin Gastroenterol 33:215-217. doi:10.1097/00004836-200109000-00009 CrossRefPubMed Scolapio JS, Spangler PR, Romano, Michelle M, McLaughlin MP, Salassa JR (2001) Prophylactic placement of gastrostomy feeding tubes before radiotherapy in patients with head and neck cancer: Is it worthwhile?. J Clin Gastroenterol 33:215-217. doi:10.​1097/​00004836-200109000-00009 CrossRefPubMed
84.
go back to reference Zogbaum AT, Fitz P, Duffy V (2004) Tube feeding may improve adherence to radiation treatment schedule in head and neck cancer. Topics Clin Nutr 19:95–106 Zogbaum AT, Fitz P, Duffy V (2004) Tube feeding may improve adherence to radiation treatment schedule in head and neck cancer. Topics Clin Nutr 19:95–106
87.
go back to reference Chasen MR, Dippenaar AP (2008) Cancer nutrition and rehabilitation—its time has come!. Curr Oncol 15(3):117–122CrossRefPubMed Chasen MR, Dippenaar AP (2008) Cancer nutrition and rehabilitation—its time has come!. Curr Oncol 15(3):117–122CrossRefPubMed
Metadata
Title
A descriptive review of the factors contributing to nutritional compromise in patients with head and neck cancer
Authors
Martin R. Chasen
Ravi Bhargava
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 11/2009
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-009-0684-5

Other articles of this Issue 11/2009

Supportive Care in Cancer 11/2009 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine