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Supportive Care in Cancer
Published in: Supportive Care in Cancer 2/2005

01-02-2005 | Review Article

Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy

Authors: Mark G. Kris, Paul J. Hesketh, Jorn Herrstedt, Cynthia Rittenberg, Lawrence H. Einhorn, Steven Grunberg, Jim Koeller, Ian Olver, Sussanne Borjeson, Enzo Ballatori

Published in: Supportive Care in Cancer | Issue 2/2005

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Abstract

This paper uses an evidence-based approach whenever possible to formulate recommendations, emphasizing the results of controlled trials concerning the best use of antiemetic agents. We address issues of dose, schedule, and route of administration of five selective 5-HT3 antagonists. We conclude that for each of these five drugs, there is a plateau in therapeutic efficacy above which further dose escalation does not improve outcome. Furthermore, for all classes of antiemetic agents, a single dose is as effective as multiple doses or a continuous infusion. The oral route is as efficacious as the intravenous route of administration, even with chemotherapy of high emetic risk. Selective antagonists of the type 3 serotonin receptor (5-HT3) in combination with dexamethasone and aprepitant are the standard of care for the prevention of emesis following chemotherapy of high emetic risk.
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Metadata
Title
Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy
Authors
Mark G. Kris
Paul J. Hesketh
Jorn Herrstedt
Cynthia Rittenberg
Lawrence H. Einhorn
Steven Grunberg
Jim Koeller
Ian Olver
Sussanne Borjeson
Enzo Ballatori
Publication date
01-02-2005
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 2/2005
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-004-0699-x

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