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25-01-2022 | Peritoneal Dialysis | Editorial Commentary

Is my PET in my genes?

Authors: Mallory Downie, Rukshana Shroff, Detlef Bockenhauer

Published in: Pediatric Nephrology | Issue 6/2022

Excerpt

Precision medicine holds the promise of individualized care. Thus, while traditional evidence-based medicine, with its reliance on large randomized controlled trials, can only provide prognostic and treatment information for a defined group of patients, precision medicine aims to go beyond that, by providing accurate information on treatment response and prognosis for each individual patient. Thereby, precision medicine tries to address the problem of the large spectrum of severity within a given clinical group, by identifying the genetic and environmental factors that contribute to the phenotypic diversity. Imagine that you could with reasonable accuracy predict beforehand whether a patient with, for instance, IgA nephropathy will eventually have spontaneous resolution or progressive chronic kidney disease, whether this will respond to immunosuppression and, if so, which drug will work best with the least side effects! Or, as we will discuss here, whether a patient with kidney failure is likely to do well on peritoneal dialysis (PD) or not and with what kind of PD prescription. …

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Title: Is my PET in my genes?
Authors: Mallory Downie
Rukshana Shroff
Detlef Bockenhauer
Publication date: 25-01-2022
Publisher: Springer Berlin Heidelberg
Keyword: Peritoneal Dialysis
Published in: Pediatric Nephrology / Issue 6/2022
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-022-05452-1

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