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01-07-2021 | Nephrotic Syndrome | Original Article

Determination of the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the diagnosis of asymptomatic pulmonary embolism in patients with nephrotic syndrome

Authors: Nasrin Hoseiny nejad, Amin Sadat Sharif, Hasan Otukesh, Rozita Hosseini shamsabadi, Sepideh Hekmat, Maryam Sakhaei

Published in: Pediatric Nephrology | Issue 7/2021

Abstract

Background

Thromboembolism is one of the most important and dangerous complications of nephrotic syndrome. This study aimed to determine the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the prediction of asymptomatic pulmonary embolism in patients with nephrotic syndrome in non-remission period.

Methods

Plasma levels of albumin, anti-thrombin III, fibrinogen and D-dimer were assessed in 30 nephrotic children in non-remission period (including new case–patient or relapse period), and the results were compared with chest X-ray and lung perfusion scintigraphy (Q scan).

Results

The mean age of patients was 6.22 ± 3.5 years (range 2–12 years). Of patients, 23.3% had abnormal findings in perfusion scan suggestive of pulmonary emboli despite absence of any respiratory manifestations. Median plasma albumin and anti-thrombin III levels in patients with asymptomatic pulmonary embolism were lower than in patients without pulmonary embolism. Also, median fibrinogen and D-dimer levels in patients with asymptomatic pulmonary embolism were higher than in patients without pulmonary embolism, with no statistically significant differences between sex, age, hemoglobin and hematocrit of patients and lung perfusion scan results.

Conclusion

Patients with abnormal blood levels of albumin (< 3.5 g/dl), anti-thrombin III (< 80 ml/dl), fibrinogen (> 400 ml/dl) and D-dimer (> 0.5 μg/dl) underwent CXR/Q scan and were treated with heparin if there was pulmonary embolism.

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Title: Determination of the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the diagnosis of asymptomatic pulmonary embolism in patients with nephrotic syndrome
Authors: Nasrin Hoseiny nejad
Amin Sadat Sharif
Hasan Otukesh
Rozita Hosseini shamsabadi
Sepideh Hekmat
Maryam Sakhaei
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keyword: Nephrotic Syndrome
Published in: Pediatric Nephrology / Issue 7/2021
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-020-04904-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Determination of the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the diagnosis of asymptomatic pulmonary embolism in patients with nephrotic syndrome

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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