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Published in: Pediatric Nephrology 3/2021

01-03-2021 | Antibiotic | Review

New therapeutic perspectives for IgA nephropathy in children

Authors: Alexandra Cambier, Patrick J. Gleeson, Héloise Flament, Marie-Bénédicte Le Stang, Renato C. Monteiro

Published in: Pediatric Nephrology | Issue 3/2021

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Abstract

Childhood IgA nephropathy (cIgAN) differs from the adult by having an abrupt clinical onset, often presenting as an acute attack that can progress to a chronic phase. No treatment guidelines have been established for the treatment of cIgAN. Given the severity of acute attack in children, and the number of life-years at stake, pediatricians prescribe immunosuppression in addition to renin–angiotensin system blockade. Non-specific immunosuppressors, such as corticosteroids, have systemic toxic effects, and given recent therapeutic advances in adult glomerulonephritis, new tailored strategies should be expected for children. The mucosal immune system has been highlighted as a key player in IgAN pathogenesis, and several biomarkers have been identified with a direct role in pathogenesis. In this review, we discuss current studies of conventional and novel therapeutic approaches for cIgAN.
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Metadata
Title
New therapeutic perspectives for IgA nephropathy in children
Authors
Alexandra Cambier
Patrick J. Gleeson
Héloise Flament
Marie-Bénédicte Le Stang
Renato C. Monteiro
Publication date
01-03-2021
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 3/2021
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-020-04475-w

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