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Open Access 01-09-2016 | Original Article

Impaired longitudinal deformation measured by speckle-tracking echocardiography in children with end-stage renal disease

Authors: Maike van Huis, Nikki J. Schoenmaker, Jaap W. Groothoff, Johanna H. van der Lee, Maria van Dyk, Marc Gewillig, Linda Koster, Ronald Tanke, Marc Lilien, Nico A. Blom, Luc Mertens, Irene M. Kuipers

Published in: Pediatric Nephrology | Issue 9/2016

Abstract

Background

Left ventricular dysfunction is an important co-morbidity of end-stage renal disease (ESRD) and is associated with a poor prognosis in the adult population. In pediatric ESRD, left ventricular function is generally well preserved, but limited information is available on early changes in myocardial function. The aim of this study was to investigate myocardial mechanics in pediatric patients with ESRD using speckle-tracking echocardiography (STE).

Methods

Echocardiographic studies, including M-mode, tissue Doppler imaging (TDI) and STE, were performed in 19 children on dialysis, 17 transplant patients and 33 age-matched controls. Strain measurements were performed from the apical four-chamber and the short axis view, respectively.

Results

The interventricular and left ventricular posterior wall thickness was significantly increased in dialysis and transplant patients compared to healthy controls. No significant differences were found in shortening fraction, ejection fraction and systolic tissue Doppler velocities. Dialysis and transplant patients had a decreased mean longitudinal strain compared to healthy controls, with a mean difference of 3.1 [95 % confidence interval (CI) 2.0–4.4] and 2.7 (95 % CI 1.2–4.2), respectively. No differences were found for radial and circumferential strain.

Conclusions

Speckle-tracking echocardiography may reveal early myocardial dysfunction in the absence of systolic dysfunction measured by conventional ultrasound or TDI in children with ESRD.

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Title: Impaired longitudinal deformation measured by speckle-tracking echocardiography in children with end-stage renal disease
Authors: Maike van Huis
Nikki J. Schoenmaker
Jaap W. Groothoff
Johanna H. van der Lee
Maria van Dyk
Marc Gewillig
Linda Koster
Ronald Tanke
Marc Lilien
Nico A. Blom
Luc Mertens
Irene M. Kuipers
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 9/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-016-3362-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impaired longitudinal deformation measured by speckle-tracking echocardiography in children with end-stage renal disease

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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