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Pediatric Nephrology
Published in: Pediatric Nephrology 1/2016

01-01-2016 | Original Article

Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort

Authors: Juhi Kumar, Kelly McDermott, Alison G. Abraham, Lisa Aronson Friedman, Valerie L. Johnson, Frederick J. Kaskel, Susan L. Furth, Bradley A. Warady, Anthony A. Portale, Michal L. Melamed

Published in: Pediatric Nephrology | Issue 1/2016

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Abstract

Background

Vitamin D plays an important role in the mineral and bone disorder seen in chronic kidney disease (CKD). Deficiency of 25-hydroxyvitamin D (25OHD) is highly prevalent in the adult CKD population.

Methods

The prevalence and determinants of 25OHD deficiency (defined as a level <20 ng/ml) were examined longitudinally in 506 children in the CKiD cohort. Predictors of secondary hyperparathyroidism and the determinants of 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were also evaluated.

Results

Deficiency of 25OHD was observed in 28 % of the cohort at enrollment. Significant predictors of 25OHD deficiency were older age, non-white race, higher body mass index, assessment during winter, less often than daily milk intake, non-use of nutritional vitamin D supplement and proteinuria. Lower values of glomerular filtration rate (GFR), serum 25OHD, calcium and higher levels of FGF23 were significant determinants of secondary hyperparathyroidism. Lower GFR, low serum 25OHD, nephrotic-range proteinuria, and high FGF23 levels were significant determinants of serum 1,25(OH)2 D levels.

Conclusions

Deficiency of 25OHD is prevalent in children with CKD and is associated with potentially modifiable risk factors such as milk intake, nutritional vitamin D supplement use, and proteinuria. 25OHD deficiency is a risk factor for secondary hyperparathyroidism and decreased serum 1,25(OH)2D in children with CKD.
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Metadata
Title
Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort
Authors
Juhi Kumar
Kelly McDermott
Alison G. Abraham
Lisa Aronson Friedman
Valerie L. Johnson
Frederick J. Kaskel
Susan L. Furth
Bradley A. Warady
Anthony A. Portale
Michal L. Melamed
Publication date
01-01-2016
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 1/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-015-3190-7

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