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01-12-2015 | Original Article

Long-term outcome of childhood IgA nephropathy with minimal proteinuria

Authors: Asumi Higa, Yuko Shima, Taketsugu Hama, Masashi Sato, Hironobu Mukaiyama, Hiroko Togawa, Ryojiro Tanaka, Kandai Nozu, Mayumi Sako, Kazumoto Iijima, Koichi Nakanishi, Norishige Yoshikawa

Published in: Pediatric Nephrology | Issue 12/2015

Abstract

Background

Some patients with childhood immunoglobulin A nephropathy (IgAN) progress to end-stage renal disease within 20 years, while others achieve spontaneous remission even without medication. Prognosis of IgAN with minimal proteinuria (MP-IgAN, <0.5 g/day/1.73 m²) at diagnosis seems to be generally good. However, the long-term outcome for patients with childhood MP-IgAN has not yet been determined.

Methods

We retrospectively analyzed 385 children newly diagnosed with biopsy-proven IgAN between June 1976 and July 2009 whose renal biopsy specimens could be evaluated by the Oxford classification criteria. Of these 385 children with IgAN, 106 (27.5 %) were diagnosed with MP-IgAN. We compared clinical and pathological findings between the 106 patients with MP-IgAN and the remaining 279 patients to elucidate the characteristics of MP-IgAN in children.

Results

Patients with MP-IgAN were identified through a school screening program (73.6 %) or upon presentation with gross hematuria (26.4 %). Patients with MP-IgAN had significantly milder pathological symptoms than those with IgAN. The most frequently used therapeutic regimes were angiotensin converting enzyme inhibitors (30.2 %) and no therapy (36.8 %). None of the patients with MP-IgAN reached stage III chronic kidney disease within 15 years after onset. Four patients with MP-IgAN (3.8 %) received immunosuppressive therapy during the course of the disease.

Conclusion

Our results indicate that the outcome of patients with a diagnosis of childhood MP-IgAN is good, but that careful long-term observation is required.

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Title: Long-term outcome of childhood IgA nephropathy with minimal proteinuria
Authors: Asumi Higa
Yuko Shima
Taketsugu Hama
Masashi Sato
Hironobu Mukaiyama
Hiroko Togawa
Ryojiro Tanaka
Kandai Nozu
Mayumi Sako
Kazumoto Iijima
Koichi Nakanishi
Norishige Yoshikawa
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 12/2015
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-015-3176-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-term outcome of childhood IgA nephropathy with minimal proteinuria

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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