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Pediatric Nephrology

Published in:

01-04-2015 | Original Article

Probiotics prophylaxis in infants with primary vesicoureteral reflux

Authors: Seung Joo Lee, Jung Won Lee

Published in: Pediatric Nephrology | Issue 4/2015

Abstract

Background

In this era of increasing bacterial resistance to antimicrobial therapy, probiotics have great potential and yet they are a harmless alternative approach. This study is a prospective randomized uncontrolled trial to investigate the preventive effect of probiotic prophylaxis in infants with primary vesicoureteral reflux (VUR) and frequently recurring urinary tract infection (UTI) during the first follow-up year.

Methods

One hundred and twenty-eight infants (aged 1 week to 12 months) with primary VUR were prospectively randomized into a probiotic (n = 64, Lactobacillus acidophilus, 1.0 × 10⁸ CFU/g) or antibiotic (n = 64, trimethoprim/sulfamethoxazole, 2/10 mg/kg) group.

Results

The incidence of recurrent UTI in the probiotic group was slightly lower than in the antibiotic group without statistical significance (32.8 % [21 out of 64] vs 40.6 % [26/64]) (P = 0.348). Causative organisms of recurrent UTI, resolution rate of VUR, and development of renal scarring were not different between the probiotic and antibiotic prophylaxis groups. The incidences of antibiotic resistance of causative organisms in recurrent UTI were significantly lower in the probiotic group than in the antibiotic group.

Conclusions

Probiotics could be considered a natural alternative regimen for prophylaxis in infants with primary VUR.

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Title: Probiotics prophylaxis in infants with primary vesicoureteral reflux
Authors: Seung Joo Lee
Jung Won Lee
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 4/2015
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2988-z

2024 ASCO Annual Meeting

Springer Medicine

Probiotics prophylaxis in infants with primary vesicoureteral reflux

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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