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01-06-2015 | Review

Metabolomics in pediatric nephrology: emerging concepts

Authors: Mina H. Hanna, Patrick D. Brophy

Published in: Pediatric Nephrology | Issue 6/2015

Abstract

Metabolomics, the latest of the “omics” sciences, refers to the systematic study of metabolites and their changes in biological samples due to physiological stimuli and/or genetic modification. Because metabolites represent the downstream expression of genome, transcriptome, and proteome, they can closely reflect the phenotype of an organism at a specific time. As an emerging field in analytical biochemistry, metabolomics has the potential to play a major role in monitoring real-time kidney function and detecting adverse renal events. Additionally, small molecule metabolites can provide mechanistic insights into novel biomarkers of kidney diseases, given the limitations of the current traditional markers. The clinical utility of metabolomics in the field of pediatric nephrology includes biomarker discovery, defining as yet unrecognized biological therapeutic targets, linking of metabolites to relevant standard indices and clinical outcomes, and providing a window of opportunity to investigate the intricacies of environment/genetic interplay in specific disease states.

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Title: Metabolomics in pediatric nephrology: emerging concepts
Authors: Mina H. Hanna
Patrick D. Brophy
Publication date: 01-06-2015
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 6/2015
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-014-2880-x

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Springer Medicine

Metabolomics in pediatric nephrology: emerging concepts

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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