Differential diagnosis includes post-transplant lymphoproliferative disorder (PTLD), renal cell carcinoma, fungal infection, and malakoplakia.
2.
Sheets of large polygonal cells with abundant granular eosinophilic cytoplasm. No normal renal parenchyma is seen (see Fig. 1a). Michaelis–Gutmann bodies are seen as pale basophilic rounded inclusions within the cytoplasm (arrows in Fig. 1b).
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3.
Malakoplakia in the renal allograft is often treated with a prolonged course of antibiotics and require reduction of immunosuppression.