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01-05-2014 | Original Article

Subsequent cancer risk of children receiving post voiding cystourethrography: A nationwide population-based retrospective cohort study

Authors: Yen-Hsiu Liao, Cheng-Li Lin, Chang-Ching Wei, Po-Pang Tsai, Wu-Chung Shen, Fung-Chang Sung, Tsai-Chung Li, Chia-Hung Kao

Published in: Pediatric Nephrology | Issue 5/2014

Abstract

Background

To estimate the subsequent cancer risk of children receiving post voiding cystourethrography (VCUG), a nationwide population-based retrospective cohort study with the data from the Taiwan National Health Insurance Research Database (NHIRD) were used for the analysis.

Methods

In the VCUG cohort, 31,908 participants younger than 18 years of age who underwent VCUG between 1997 and 2008 were identified from the NHIRD. A comparison cohort, the non-VCUG cohort, was randomly selected among children without VCUG examination histories during 1997–2008, frequency matched for age (every 5 years), sex, geographic region area, parents’ occupation, and index year based on a 1:4 ratio. Cox’s proportional hazard regression analysis was conducted to estimate the subsequent cancer risk of children receiving VCUG.

Results

The overall cancer risk of the VCUG cohort is 1.92-fold (95 % CI = 1.34–2.74) higher than that of the non-VCUG cohort with statistical significance. The genital cancer and urinary system cancer risks of the VCUG cohort are respectively 6.19-fold (95 % CI = 1.37–28.0) and 5.8-fold (95 % CI = 1.54–21.9) higher than those of the non-VCUG cohort with statistical significance. The hazard ratios are higher in genital cancer, urinary system cancer (the major radiation exposure area), and cancer of the abdomen, except for the genitourinary system (the minor radiation exposure area), in sequence.

Conclusions

Pediatric VCUG is associated with increased subsequent cancer risk, especially in the genitourinary system.

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Title: Subsequent cancer risk of children receiving post voiding cystourethrography: A nationwide population-based retrospective cohort study
Authors: Yen-Hsiu Liao
Cheng-Li Lin
Chang-Ching Wei
Po-Pang Tsai
Wu-Chung Shen
Fung-Chang Sung
Tsai-Chung Li
Chia-Hung Kao
Publication date: 01-05-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 5/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-013-2703-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Subsequent cancer risk of children receiving post voiding cystourethrography: A nationwide population-based retrospective cohort study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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