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01-04-2014 | Review

BMP signaling and its modifiers in kidney development

Authors: Ryuichi Nishinakamura, Masaji Sakaguchi

Published in: Pediatric Nephrology | Issue 4/2014

Abstract

The kidney develops through mutual interactions between the metanephric mesenchyme and the ureteric bud, the former of which contains nephron progenitors that give rise to glomeruli and renal tubules. Bone morphogenetic protein (BMP) signaling and its modifiers play important roles in many steps of kidney development. BMP4 inhibits ureteric bud attraction, and the BMP antagonist Gremlin is essential for the initial stage of ureteric budding. During mid-gestation, BMP7 maintains the nephron progenitors and, at the same time, sensitizes them to the ureteric bud-derived differentiation signal. Crossveinless2 is a pro-BMP factor, and its absence leads to kidney hypoplasia. After birth, when nephron progenitors have disappeared, Dullard, a phosphatase that inactivates BMP receptors, keeps BMP signaling at an appropriate level. Deletion of Dullard results in excessive BMP signaling and apoptosis of the postnatal nephrons. In this review I discuss the similarities and differences of BMP functions in kidney development, as well as in diseases.

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Title: BMP signaling and its modifiers in kidney development
Authors: Ryuichi Nishinakamura
Masaji Sakaguchi
Publication date: 01-04-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 4/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-013-2671-9

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BMP signaling and its modifiers in kidney development

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