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01-02-2014 | Original Article

Growth and function in childhood of a normal solitary kidney from birth or from early infancy

Authors: Ekaterini Siomou, Vasileios Giapros, Frederica Papadopoulou, Maria Pavlou, Andreas Fotopoulos, Antigoni Siamopoulou

Published in: Pediatric Nephrology | Issue 2/2014

Abstract

Background

Children with a solitary kidney (SK) have an increased long-term risk of hypertension, albuminuria and glomerulosclerosis. In this study, we assessed the early signs of impaired glomerular filtration in children with a SK from birth or from early infancy.

Methods

Renal growth and function at ages 4–15.5 years were studied in 38 children with SK and 40 matched control subjects in terms of accelerated growth.

Results

The systolic/diastolic blood pressure Z-scores (p = 0.01/<0.05) and the resistance index (RI) of the arcuate arteries (p = 0.05) were higher in the children with SK. Creatinine clearance and 24-h protein and albumin urinary excretion showed no difference. All but seven children with SK had 99mTc diethylene-triamine pentaacetic acid glomerular filtration rate values of >80 ml/min/1.73 m². An independent positive correlation was found between length of the follow-up time and 24-h albumin urinary excretion (β = 0.54, p < 0.01). Accelerated postnatal growth was positively related with kidney volume (β = 0.35, p < 0.05).

Conclusions

Among our patient cohort, renal function was well preserved at ages 4–15.5 years in children who were born with a SK. However, both their higher blood pressure and RI and the correlation of 24-h albumin urinary excretion with length of follow-up time underline the need for monitoring to detect early signs of glomerular hyperfiltration and, if necessary, implement timely intervention. SK hypertrophy was found to be correlated with postnatal growth.

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Title: Growth and function in childhood of a normal solitary kidney from birth or from early infancy
Authors: Ekaterini Siomou
Vasileios Giapros
Frederica Papadopoulou
Maria Pavlou
Andreas Fotopoulos
Antigoni Siamopoulou
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 2/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-013-2623-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Growth and function in childhood of a normal solitary kidney from birth or from early infancy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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