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Pediatric Nephrology
Published in: Pediatric Nephrology 1/2014

01-01-2014 | Original Article

Efficacy and safety of intermittent hemodialysis in infants and young children with inborn errors of metabolism

Authors: I-Jung Tsai, Wuh-Liang Hwu, Shu-Chien Huang, Ni-Chung Lee, En-Ting Wu, Yin-Hsiu Chien, Yong-Kwei Tsau

Published in: Pediatric Nephrology | Issue 1/2014

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Abstract

Background

Intermittent hemodialysis (IHD) is the most efficient form of renal replacement therapy (RRT) for removing toxic substances from patients’ bodies. However, the efficacy and safety of IHD in infants and young children with inborn errors of metabolism are still not clear.

Methods

This retrospective study included patients with urea cycle disorders, maple syrup urine disease, and methylmalonic acidemia who received IHD or non-IHD RRT at our hospital between 2001 and 2012 to remove ammonia, leucine, or methylmalonic acid. Both the efficacy and safety of the RRT were evaluated.

Results

Thirty-five courses of RRT, including 25 courses of IHD and ten courses of non-IHD RRT, for 15 patients were included in the analysis. Before 2006, non-IHD RRT procedures, including peritoneal dialysis (PD) and continuous venous-venous hemofiltration (CVVH), were the most often used; from 2006 onwards IHD was used. There was one procedure-unrelated death. Catheter penetration occurred in one course of IHD. The efficacy data revealed that both the median duration of dialysis and the median 50 % toxin reduction time were shorter in IHD than in non-IHD RRT.

Conclusions

In infants and young children with inborn errors of metabolism, IHD is safe and more efficient than non-IHD RRT at removing toxins.
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Metadata
Title
Efficacy and safety of intermittent hemodialysis in infants and young children with inborn errors of metabolism
Authors
I-Jung Tsai
Wuh-Liang Hwu
Shu-Chien Huang
Ni-Chung Lee
En-Ting Wu
Yin-Hsiu Chien
Yong-Kwei Tsau
Publication date
01-01-2014
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 1/2014
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-013-2609-2

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