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01-09-2012 | Original Article

Intima media thickness in children undergoing dialysis

Authors: Luis Antonio Chavarria, Alejandra Aguilar-Kitsu, Patricia Rosas, Arturo Fajardo, Leticia Mendoza-Guevara, Lorena Sanchez, Claudia Zepeda, Pilar Ibarra, Alejandro Luna, Bengt Lindholm, Elvia García-López

Published in: Pediatric Nephrology | Issue 9/2012

Abstract

Background

Uremic vasculopathy, including vascular calcification, increases the risk for cardiovascular disease and mortality in chronic kidney disease (CKD) patients. We have investigated the prevalence and factors associated with vasculopathy in children undergoing peritoneal dialysis (PD) or hemodialysis (HD) in a single center.

Methods

Common carotid intima media thickness (cIMT) and its relation with demographics, biochemical parameters and medication was analyzed in 60 patients (mean age 12.9 ± 3.4 years; 27 girls) treated with PD (n = 31) or HD (n = 29) for 34 ± 34 months. Patients were divided into two groups: normal cIMT and increased cIMT.

Results

Mean levels of calcium, phosphate and calcium/phosphate product were in the normal range, the but parathyroid hormone level, 729 ± 670 pg/mL, was higher than the National Kidney Foundation Kidney Disease Outcome Quality Iniative (K/DOQI) recommendations. Twenty-nine patients had increased cIMT, which was associated with time on dialysis of >2 years, hypercalcemia, higher daily dose of calcitriol and HD (vs. PD). In the multivariate analysis, accounting for time on dialysis, HD persisted as a risk for increased cIMT.

Conclusions

The prevalence of increased cIMT in children on dialysis is similar to that reported in adults with CKD and increased with time on dialysis. HD was associated with increased cIMT, independently of time on dialysis; however, the results should be interpreted with caution due to the possible impact of confounding factors. These results underline the need to monitor and, if possible, prevent and treat increased cIMT in children on dialysis.

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Title: Intima media thickness in children undergoing dialysis
Authors: Luis Antonio Chavarria
Alejandra Aguilar-Kitsu
Patricia Rosas
Arturo Fajardo
Leticia Mendoza-Guevara
Lorena Sanchez
Claudia Zepeda
Pilar Ibarra
Alejandro Luna
Bengt Lindholm
Elvia García-López
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 9/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2173-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intima media thickness in children undergoing dialysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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