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Pediatric Nephrology
Published in: Pediatric Nephrology 8/2012

01-08-2012 | Review

Investigating mechanisms of chronic kidney disease in mouse models

Authors: Allison A. Eddy, Jesús M. López-Guisa, Daryl M. Okamura, Ikuyo Yamaguchi

Published in: Pediatric Nephrology | Issue 8/2012

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Abstract

Animal models of chronic kidney disease (CKD) are important experimental tools that are used to investigate novel mechanistic pathways and to validate potential new therapeutic interventions prior to pre-clinical testing in humans. Over the past several years, mouse CKD models have been extensively used for these purposes. Despite significant limitations, the model of unilateral ureteral obstruction (UUO) has essentially become the high-throughput in vivo model, as it recapitulates the fundamental pathogenetic mechanisms that typify all forms of CKD in a relatively short time span. In addition, several alternative mouse models are available that can be used to validate new mechanistic paradigms and/or novel therapies. Here, we review several models—both genetic and experimentally induced—that provide investigators with an opportunity to include renal functional study end-points together with quantitative measures of fibrosis severity, something that is not possible with the UUO model.
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Metadata
Title
Investigating mechanisms of chronic kidney disease in mouse models
Authors
Allison A. Eddy
Jesús M. López-Guisa
Daryl M. Okamura
Ikuyo Yamaguchi
Publication date
01-08-2012
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 8/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-011-1938-2

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