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01-10-2011 | Educational Review

Rhabdomyolysis: pathogenesis of renal injury and management

Authors: Zubaida Al-Ismaili, Melissa Piccioni, Michael Zappitelli

Published in: Pediatric Nephrology | Issue 10/2011

Excerpt

Rhabdomyolysis refers to the breakdown of skeletal muscle due to either a physical, biological, or toxic injury that leads to leakage of muscle contents, such as myoglobin and creatinine kinase (CK), into the extracellular fluid. This syndrome is classically characterized clinically by muscle weakness and pain and at times tea-colored urine. Serum myoglobin is filtered by the glomerulus, leading to myoglobinuria. This may lead to direct renal tubular injury and a clinical presentation ranging from mild to life-threatening acute kidney injury (AKI). …

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Title: Rhabdomyolysis: pathogenesis of renal injury and management
Authors: Zubaida Al-Ismaili
Melissa Piccioni
Michael Zappitelli
Publication date: 01-10-2011
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 10/2011
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-010-1727-3

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Rhabdomyolysis: pathogenesis of renal injury and management

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