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01-12-2010 | Original Article

Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease

Authors: Maria Fernanda Soares Naufel, Milena Bordon, Talita Marques de Aquino, Eliane Beraldi Ribeiro, João Tomás de Abreu Carvalhaes

Published in: Pediatric Nephrology | Issue 12/2010

Abstract

This cross-sectional study set out to compare total and acyl ghrelin levels in children with mild chronic kidney disease (CKD) undergoing conservative treatment (n = 19) with children with end-stage renal disease (ESRD) undergoing hemodialysis (n = 24), and with healthy controls (n = 20). The relationship between ghrelin levels and parameters of renal function, nutritional status, and selective hormones were investigated. ESRD patients had higher total ghrelin levels than those with mild CKD or control individuals. However, acyl ghrelin did not differ between groups, indicating that the excess circulating ghrelin was desacylated. Since desacyl ghrelin has been shown to inhibit appetite, increased levels might contribute to protein-energy wasting in pediatric renal patients. When all 43 renal patients were combined, multiple regression analysis found age and glomerular filtration rate (GFR) to be significant negative predictors of total ghrelin. Acyl ghrelin was influenced negatively by age and positively by energy intake. Acyl to total ghrelin ratio related positively to GFR and energy intake. The results indicate that total but not acyl ghrelin is influenced by low GFR in children with CKD and suggests that ghrelin activation may be impaired in these patients. Since energy intake is a positive predictor of acyl ghrelin, the physiological control of ghrelin secretion appears to be altered in pediatric renal patients.

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Title: Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease
Authors: Maria Fernanda Soares Naufel
Milena Bordon
Talita Marques de Aquino
Eliane Beraldi Ribeiro
João Tomás de Abreu Carvalhaes
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 12/2010
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-010-1628-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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