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01-01-2011 | Review

Biomarkers of acute kidney injury in children: discovery, evaluation, and clinical application

Authors: Zubaida Al-Ismaili, Ana Palijan, Michael Zappitelli

Published in: Pediatric Nephrology | Issue 1/2011

Abstract

Acute kidney injury (AKI) in children is associated with increased mortality and prolonged length of hospital stay and may also be associated with long-term chronic kidney disease development. Despite encouraging results on AKI treatment in animal studies, no specific treatment has yet been successful in humans. One of the important factors contributing to this problem is the lack of an early AKI diagnostic test. Serum creatinine, the current main diagnostic test for AKI, rises late in AKI pathophysiology and is an inaccurate marker of acute changes in glomerular filtration rate. Therefore, new biomarkers of AKI are needed. With great advancements in genomics, proteomics, and metabolomics, new AKI biomarkers, mainly consisting of urinary proteins that appear in response to renal tubular cell injury, have been, and continue to be, discovered. These new biomarkers offer promise for early AKI diagnosis and for the depiction of severity of renal injury occurring with AKI. This review provides a summary of what a biomarker is, why we need new biomarkers of AKI, and how biomarkers are discovered and should be evaluated. The review also provides a summary of selected AKI biomarkers that have been studied in children.

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Title: Biomarkers of acute kidney injury in children: discovery, evaluation, and clinical application
Authors: Zubaida Al-Ismaili
Ana Palijan
Michael Zappitelli
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 1/2011
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-010-1576-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Biomarkers of acute kidney injury in children: discovery, evaluation, and clinical application

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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