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01-06-2010 | Original Article

Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers

Authors: Justine Bacchetta, Sonia Fargue, Stéphanie Boutroy, Odile Basmaison, Nicolas Vilayphiou, Ingrid Plotton, Fitsum Guebre-Egziabher, Bruno Dohin, Rémi Kohler, Pierre Cochat

Published in: Pediatric Nephrology | Issue 6/2010

Abstract

The deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria type 1 (PH1). We report here an evaluation of the bone status of 12 PH1 children based on bone biomarkers [parathyroid hormone, vitamin D, fibroblast growth factor 23 (FGF23)] and radiological assessments (skeletal age, three-dimensional high-resolution peripheral quantitative computed tomography, HR-pQCT) carried out within the framework of a cross-sectional single-center study. The controls consisted of healthy and children with chronic kidney disease already enrolled in local bone and mineral metabolism studies. The mean age (±standard deviation) age of the patients was 99 (±63) months. Six children suffered from fracture. Bone maturation was accelerated in five patients, four of whom were <5 years. The combination of new imaging techniques and biomarkers highlighted new and unexplained features of PH1: advanced skeletal age in young PH1 patients, increased FGF23 levels and decreased total volumetric bone mineral density with bone microarchitecture alteration.

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Title: Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers
Authors: Justine Bacchetta
Sonia Fargue
Stéphanie Boutroy
Odile Basmaison
Nicolas Vilayphiou
Ingrid Plotton
Fitsum Guebre-Egziabher
Bruno Dohin
Rémi Kohler
Pierre Cochat
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 6/2010
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-010-1453-x

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Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers

Abstract

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Abstract

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