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01-03-2008 | Original Article

The influence of urinary flow rate in children on excretion of markers used for assessment of renal damage: albumin, γ-glutamyl transpeptidase, N-acetyl-β-D-glucosaminidase, and alpha1-microglobulin

Authors: Felicia Trachtenberg, Lars Barregard, Sonja McKinlay

Published in: Pediatric Nephrology | Issue 3/2008

Abstract

The aim of the present study was to examine the influence of urinary flow rate on markers of renal function in children. A sub-study of the New England Children’s Amalgam Trial collected 82 pairs of urine samples from children aged 10–16 years: a timed overnight collection and a spot daytime sample collected the following day. These samples were analyzed for albumin, γ-glutamyl transpeptidase (γ-GT), N-acetyl-β-D-glucosaminidase (NAG), alpha1-microglobulin (A1M), and creatinine concentration. Regression analysis was used to model the effect of urinary flow rate in the timed overnight samples. A paired t-test compared concentrations and creatinine-corrected renal markers between overnight and daytime samples. Albumin, γ-GT, NAG, and A1M excretion rates increased significantly with urinary flow rate. Their corresponding creatinine-corrected markers did not vary significantly with urinary flow rate, but the creatinine-corrected excretions of albumin, γ-GT, and NAG were significantly higher in daytime samples than in overnight samples, with the same (non-significant) trend for A1M. The influence of urinary flow rate on creatinine-corrected markers of renal function was markedly less than its influence on excretion rates. Therefore, the use of creatinine-corrected markers seems to be a good choice in practice, with the caveat that daytime and overnight samples are not comparable.

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Title: The influence of urinary flow rate in children on excretion of markers used for assessment of renal damage: albumin, γ-glutamyl transpeptidase, N-acetyl-β-D-glucosaminidase, and alpha1-microglobulin
Authors: Felicia Trachtenberg
Lars Barregard
Sonja McKinlay
Publication date: 01-03-2008
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 3/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0568-1

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The influence of urinary flow rate in children on excretion of markers used for assessment of renal damage: albumin, γ-glutamyl transpeptidase, N-acetyl-β-D-glucosaminidase, and alpha1-microglobulin

Abstract

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