Published in:
01-10-2007 | Brief Report
Renin-angiotensin axis blockade reduces proteinuria in presymptomatic patients with familial FSGS
Authors:
Lawrence Copelovitch, Marta Guttenberg, Martin R. Pollak, Bernard S. Kaplan
Published in:
Pediatric Nephrology
|
Issue 10/2007
Login to get access
Abstract
Familial and genetic forms of focal segmental glomerulosclerosis (FSGS) are associated with six different mutations in genes affecting the podocyte (NPHS2, ACTN4, CD2AP, WT1, TRPC6, and PLCE1). Immunosuppressive agents are often unsuccessful in treating this condition. Data regarding the efficacy of renoprotection through blockage of the renin-angiotensin axis is lacking. We describe three children from two different families with familial FSGS in whom partial to complete remission of proteinuria was attained through early blockade of the renin-angiotensin axis. In addition, there was no deterioration of renal function. We speculate that presymptomatic patients with normal renal function who have genetic or familial FSGS may benefit from early blockade of the renin-angiotensin axis and that this may also prevent progressive renal disease.