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01-07-2007 | Brief Report

Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration

Authors: Timothy E. Bunchman, Gina-Marie Barletta, John W. Winters, John J. Gardner, Teri L. Crumb, Kevin D. McBryde

Published in: Pediatric Nephrology | Issue 7/2007

Abstract

An infant with a suspected inborn metabolism error was treated with a metabolic cocktail of intravenous sodium phenylacetate (NaPh) and sodium benzoate (NaBz) for hyperammonemia. Sequential hemodialysis (HD) then hemofiltration (HF) was performed due to hyperammonemia. Dialytic and convective clearance (K; ml/min) of ammonia, NaPh, and NaBz was measured. The K of ammonia was 57 and 37 for HD and HF, respectively. The K of NaBz was 37 and 12 for HD and HF, respectively. The K of NaPh was 38 and 14 ml/min for HD and HF, respectively. Despite high clearance of both NaPh and NaBz by HD and HF, the hyperammonemia was corrected.

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Title: Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration
Authors: Timothy E. Bunchman
Gina-Marie Barletta
John W. Winters
John J. Gardner
Teri L. Crumb
Kevin D. McBryde
Publication date: 01-07-2007
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 7/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0436-z

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Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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