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01-01-2007 | Original Article

Carotid artery thickness in children and young adults with end stage renal disease

Authors: Hakan M. Poyrazoğlu, Ruhan Düşünsel, Ali Yıkılmaz, Nazmi Narin, Ruksan Anarat, Zübeyde Gündüz, Abdulhakim Coşkun, Ali Baykan, Ahmet Öztürk

Published in: Pediatric Nephrology | Issue 1/2007

Abstract

Atherosclerosis is a major cause of morbidity and mortality for ESRD patients and we have little knowledge about the presence and risk factors of atherosclerosis in children with CRF. The measurement of carotid artery intima-media thickness (cIMT) using high-resolution ultrasonography is suggested as an excellent marker of subclinical atherosclerosis. In this study, we aimed to investigate the presence of atherosclerosis and to determine the relationship between atherosclerosis and some risk factors in children and young adults with ESRD. Thirty-four patients with ESRD and 20 controls were included in this study. The measurement of cIMT was performed by using a linear B-mode 7.5-MHz ultrasound transducer. We determined anemia, abnormal calcium/phosphate metabolism, hyperhomocysteinemia, hypertriglyceridemia and increased lipoprotein (a) levels in the ESRD group. The cIMT in the ESRD group was higher than in the control group (P<0.05). SBP, DBP, MAP, LVMI and LVH prevalence were statistically higher in the ESRD group (P<0.05). There were significant positive correlations between cIMT and LVMI, MBP, whereas a significant negative correlation was determined between cIMT and PTH in the ESRD group (P<0.05). When a multiple linear regression analysis was performed with cIMT as a dependent variable and LVMI, MBP, PTH, as independent variables, a significant positive correlation was determined between cIMT and LVMI (P<0.05). In conclusion, we think that arteriopathy occurs in children with ESRD. Left ventricular hypertrophy and hypertension may associate with vascular changes in children and young adults with ESRD. Further investigations are necessary to explain association of LVMI index with cIMT.

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Title: Carotid artery thickness in children and young adults with end stage renal disease
Authors: Hakan M. Poyrazoğlu
Ruhan Düşünsel
Ali Yıkılmaz
Nazmi Narin
Ruksan Anarat
Zübeyde Gündüz
Abdulhakim Coşkun
Ali Baykan
Ahmet Öztürk
Publication date: 01-01-2007
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 1/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-006-0268-2

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Carotid artery thickness in children and young adults with end stage renal disease

Abstract

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