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01-09-2005 | Brief Report

Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature

Authors: Deniz N. Cagdas, Safak Gucer, Gülsev Kale, Ali Duzova, Seza Ozen

Published in: Pediatric Nephrology | Issue 9/2005

Abstract

In familial Mediterranean fever (FMF), a genetically inherited disease characterized by fever and serositis, renal involvement is mainly AA amyloidosis. We report a patient with FMF who developed mesangial proliferative glomerulonephritis; presumably in response to colchicine treatment, the activity of the disease decreased and renal function tests and urinary findings normalized. This report emphasizes the concurrent existence of mesangial proliferative glomerulonephritis with FMF in the absence of renal amyloidosis. Due to increased inflammatory response observed in FMF, immunologic glomerular injury, a common cause of glomerulonephritis, may occur more frequently in patients with FMF.

International familial Mediterranean fever consortium (1997) Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90:797–807CrossRefPubMed

Duzova A, Bakkaloglu A, Besbas N, Topaloglu R, Ozen S, Ozaltin F, Bassoy Y, Yilmaz E (2003) Role of A-SAA in monitoring subclinical inflammation and in colchicine dosage in familial Mediterranean fever. Clin Exp Rheumatol 21:509–514PubMed

Eliakim M, Rachmilewitz W, Rosenmann R (1970) Renal manifestation in recurrent polyserositis (familial Mediterranean fever). Isr J Med Sci 6:228–245PubMed

Said R, Nasrallah N, Hamzeh Y, Tarawneh M, Al-Khateeb M (1988) Ig A nephropathy in patients with familial Mediterranean fever. Am J Nephrol 8:417–420PubMed

Said R, Hamzeh Y, Said S, Tarawneh M, Al-Khateeb M (1992). Spectrum of renal involvement in familial Mediterranean fever. Kidney Int 41:414–419PubMed

Tekin M, Yalcinkaya F, Tümer N, Çakar N, Koçak H, Özkaya N (1999) Familial Mediterranean fever-renal involvement by disease other than amyloid. Nephrol Dial Transplant 14:475–479

Akpolat T, Akpolat I, Karagoz F, Yilmaz E, Kandemir B, Ozen S (2004) Familial Mediterranean fever and glomerulonephritis and review of the literature. Rheumatol Int 24:43–45

Centola M, Wood G, Frucht DM, Galon J, Aringer M, Farrell C, Kingma DW, Hortwiz ME, Mansfield E, Holland SM, O’Shea JJ, Rosenberg HF, Malech HL, Kastner DL (2000) The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. Blood 95:3223–3231PubMed

Ozen S (2004) Renal amyloidosis in familial Mediterranean fever. Kidney Int 65:1118–1127CrossRefPubMed

10.

Chen X, Bykhovskaya Y, Tidow N, Hamon M, Bercovitz Z, Spirina O, Fischel-Ghodsian N (2000) The familial Mediterranean fever protein interacts and co-localizes with a putative Golgi transporter. Proc Soc Exp Biol Med 224:32–40CrossRefPubMed

Title: Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature
Authors: Deniz N. Cagdas
Safak Gucer
Gülsev Kale
Ali Duzova
Seza Ozen
Publication date: 01-09-2005
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 9/2005
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-005-1991-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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