Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Pediatric Nephrology
Published in: Pediatric Nephrology 8/2004

Open Access 01-08-2004 | Review

The nervous system and chronic kidney disease in children

Authors: Debbie S. Gipson, Crista E. Wetherington, Peter J. Duquette, Stephen R. Hooper

Published in: Pediatric Nephrology | Issue 8/2004

Login to get access

Abstract

This paper provides a review of the literature on the nervous system involvement incurred by children and adolescents with chronic kidney disease (CKD), with a particular focus on neuropsychological functioning. In addition to an historical overview of earlier literature, published studies from the past 14 years that address both central and peripheral nervous system function in children with CKD are reviewed (1990–2003). These studies span work in neuroimaging, electrophysiology, and neuropsychology. A key focus for this review is on variables that might affect neurodevelopmental status in these children. The paper concludes with suggestions for achieving progress in the understanding of this complication of kidney disease in children.
Literature
1.
Polinsky MS, Kaiser BA, Stover JB (1987) Neurologic development of children with severe chronic renal failure from infancy. Pediatr Nephrol 1:157–165PubMed
2.
Alfrey AC, LeGendre GR, Kaehny WD (1976) The dialysis encephalopathy syndrome. Possible aluminum intoxication. N Engl J Med 294:184–188
3.
Andreoli SP, Bergstein JM, Sherrard DJ (1984) Aluminum intoxication from aluminum-containing phosphate binders in children with azotemia not undergoing dialysis. N Engl J Med 310:1079–1084PubMed
4.
Teschan PE, Ginn HE, Bourne JR, Ward JW, Hamel B, Nunnally JC, Musso M, Vaughn WK (1979) Quantitative indices of clinical uremia. Kidney Int 15:676–697PubMed
5.
Sagales T, Gimeno V, Planella MJ, Raguer N, Bartolome J (1993) Effects of rHuEPO on Q-EEG and event-related potentials in chronic renal failure. Kidney Int 44:1109–1115PubMed
6.
Marsh JT, Brown WS, Wolcott D, Carr CR, Harper R, Schweitzer SV, Nissenson AR (1991) rHuEPO treatment improves brain and cognitive function of anemic dialysis patients. Kidney Int 39:155–163PubMed
7.
Pickett JL, Theberge DC, Brown WS, Schweitzer SU, Nissenson AR (1999) Normalizing hematocrit in dialysis patients improves brain function. Am J Kidney Dis 33:1122–1130PubMed
8.
Elzouki A, Carroll J, Butinar D, Moosa A (1994) Improved neurological outcome in children with chronic renal disease from infancy. Pediatr Nephrol 8:205–210PubMed
9.
Nichols SL, Press GA, Schneider JA, Trauner DA (1990) Cortical atrophy and cognitive performance in infantile nephropathic cystinosis. Pediatr Neurol 6:379–381CrossRefPubMed
10.
Pueschel SM, Brem AS, Nittoli P (1992) Central nervous system and renal investigations in patients with Lowe syndrome. Childs Nerv Syst 8:45–48PubMed
11.
Qvist E, Pihko H, Fagerudd P, Valanne L, Lamminranta S, Karikoski J, Sainio K, Ronnholm K, Jalanko H, Holmberg C (2002) Neurodevelopmental outcome in high-risk patients after renal transplantation in early childhood. Pediatr Transplant 6:53–62CrossRefPubMed
12.
Hurkx W, Hulstijn D, Pasman J, Rotteveel J, Visco Y, Schroder C (1995) Evoked potentials in children with chronic renal failure, treated conservatively or by continuous ambulatory peritoneal dialysis. Pediatr Nephrol 9:325–328PubMed
13.
Evers S, Tepel M, Obladen M, Suhr B, Husstedt IW, Grotemeyer KH, Zidek W (1998) Influence of end-stage renal failure and hemodialysis on event-related potentials. J Clin Neurophysiol 15:58–63CrossRefPubMed
14.
Hulstijn-Dirkmaat GM, Damhuis IH, Jetten ML, Koster AM, Schroder CH (1995) The cognitive development of pre-school children treated for chronic renal failure. Pediatr Nephrol 9:464–469PubMed
15.
Ledermann SE, Scanes ME, Fernando ON, Duffy PG, Madden SJ, Trompeter RS (2000) Long-term outcome of peritoneal dialysis in infants. J Pediatr 136:24–29PubMed
16.
Warady BA, Belden B, Kohaut E (1999) Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy. Pediatr Nephrol 13:759–765PubMed
17.
Madden SJ, Ledermann SE, Guerrero-Blanco M, Bruce M, Trompeter RS (2003) Cognitive and psychosocial outcome of infants dialysed in infancy. Child Care Health Dev. 29:55–61
18.
Lawry KW, Brouhard BH, Cunningham RJ (1994) Cognitive functioning and school performance in children with renal failure. Pediatr Nephrol 8:326–329PubMed
19.
Mendley SR, Zelko FA (1999) Improvement in specific aspects of neurocognitive performance in children after renal transplantation. Kidney Int 56:318–323CrossRefPubMed
20.
Gipson DS, McMillen JS, Ferris ME, Conley WG, Moore CB, Szuch CL (2003) Environment and participation in children with chronic kidney disease (abstract). J Am Soc Nephrol 12:206A
21.
Brouhard BH, Donaldson LA, Lawry KW, McGowan KR, Drotar D, Davis I, Rose S, Cohn RA, Tejani A (2000) Cognitive functioning in children on dialysis and post-transplantation. Pediatr Transplant 4:261–267CrossRefPubMed
22.
Fennell RS, Fennell EB, Carter RL, Mings EL, Klausner AB, Hurst JR (1990) Correlations between performance on neuropsychological tests in children with chronic renal failure. Child Nephrol Urol 10:199–204PubMed
23.
Quick CA (1976) Hearing loss in patients with dialysis and renal transplants. Ann Otol Rhinol Laryngol 85:776–790PubMed
24.
Fennell R, Fennell E, Carter R, Mings E, Klausner A (1990) Association between renal function and cognition in childhood chronic renal failure. Pediatr Nephrol 4:16–20PubMed
25.
US Department of Education (2002) Twenty-fourth annual report to Congress on the implementation of the Individuals with Disabilities Education Act. US Government Printing Office, Washington, DC
26.
Lin CL, Wu MS, Hsu PY, Huang CC (2003) Improvement of clinical outcome by early nephrology referral in type II diabetics on hemodialysis. Ren Fail 25:455–464CrossRefPubMed
27.
Dzido G, Sprague SM (2003) Dialysis-related amyloidosis. Minerva Urol Nefrol 55:121–129PubMed
28.
Davis I, Chang P, Nevins T (1990) Successful renal transplantation accelerates development in young uremic children. Pediatrics 86:594–600PubMed
29.
Limwongse C, Clarren SK, Cassidy SB (1999) Syndromes and malformations of the urinary tract. In: Barratt TM, Avner ED, Harmon WE (eds) Pediatric nephrology. Lippincott Williams and Wilkins, Baltimore
30.
Rasbury WC, Fennell R, Morris MK (1983) Cognitive functioning of children with end stage renal disease pre and post successful transplant. J Pediatrics 102:589–592
31.
Rasbury WC, Fennell RS, Fennell EB, Morris MK (1986) Cognitive functioning in children with end stage renal disease pre- and post-dialysis session. Int J Pediatr Nephrol 7:45–50PubMed
32.
National Kidney Foundation (1997) NKF-DOQI clinical practice guidelines for peritoneal dialysis adequacy. Am J Kidney Dis 30:S67–S136
33.
National Kidney Foundation (1997) NKF-DOQI clinical practice guidelines for hemodialysis adequacy. Am J Kidney Dis 30:S15–S66
34.
National Kidney Foundation-Dialysis Outcomes Quality Initiative (1997) NKF-DOQI clinical practice guidelines for the treatment of anemia of chronic renal failure. Am J Kidney Dis 30:S192–S240PubMed
35.
Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi PG (2001) Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics 107:1381–1386PubMed
36.
Lande MB, Kaczorowski JM, Auinger P, Schwartz GJ, Weitzman M (2003) Elevated blood pressure and decreased cognitive function among school-age children and adolescents in the United States. J Pediatr 143:720–724CrossRefPubMed
37.
Gorman KS (1995) Malnutrition and cognitive development: evidence from experimental/quasi-experimental studies among the mild-to-moderately malnourished. J Nutr 125:2239S–2244SPubMed
38.
Grantham-McGregor S (1995) A review of studies of the effect of severe malnutrition on mental development. J Nutr 125:2233S–2238SPubMed
39.
Levitsky DA, Strupp BJ (1995) Malnutrition and the brain: changing concepts, changing concerns. J Nutr 125:2212S–20SPubMed
40.
Ho M, Stablein DM (2003) North American Pediatric Renal Transplant Cooperative Study 2003 Annual Report. Data Coordinating Center, The EMMES Corporation, pp 1–223
41.
Stoelhorst GM, Rijken M, Martens SE, Zwieten PH van, Feenstra J, Zwinderman AH, Wit JM, Veen S (2003) Developmental outcome at 18 and 24 months of age in very preterm children: a cohort study from 1996 to 1997. Early Hum Dev 72:83–95CrossRefPubMed
42.
Caldas SJ, Bankston C (1997) Effect of school population socioeconomic status on individual academic achievement. J Educ Res 90:269–277
43.
Mancini ML, Dello SL, Bianchi PM, Tieri L, Rizzoni G (1996) Sensorineural hearing loss in patients reaching chronic renal failure in childhood. Pediatr Nephrol 10:38–40PubMed
44.
U.S. Renal Data System (2003) USRDS 2003 Annual Data Report: atlas of end-stage renal disease in the United States. National Institutes of Health, National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, Md.
Metadata
Title
The nervous system and chronic kidney disease in children
Authors
Debbie S. Gipson
Crista E. Wetherington
Peter J. Duquette
Stephen R. Hooper
Publication date
01-08-2004
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 8/2004
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-004-1532-y

Other articles of this Issue 8/2004

Pediatric Nephrology 8/2004 Go to the issue

Original Article

ACE and AT1 receptor gene polymorphisms and renal scarring in urinary bladder dysfunction

Letter to the Editors

Reply to the letter from B. Yildiz et al.

Original Article

Bartter syndrome: benefits and side effects of long-term treatment

Letter to the Editors

Phosphate binders in dialyzed patients: efficacy and cost

Brief Report

Isolated abducens nerve palsy in hemolytic uremic syndrome

Letter to the Editors

Reply to the letter from J. I. Minguela and R. Ruiz-de-Gauna