Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Pediatric Nephrology
Published in: Pediatric Nephrology 8/2004

01-08-2004 | Brief Report

Sulfadiazine-induced nephrolithiasis in children

Authors: Charlotte Catalano-Pons, Sophie Bargy, Deborah Schlecht, Marie-Dominique Tabone, George Deschênes, Albert Bensman, Tim Ulinski

Published in: Pediatric Nephrology | Issue 8/2004

Login to get access

Abstract

Sulfadiazine-associated urinary calculi have been described in HIV-positive adult patients but rarely in children. We report two pediatric cases of sulfadiazine-induced nephrolithiasis and review 45 adult cases from the literature. One had a hyper-IgM syndrome and was treated with sulfadiazine for cerebral toxoplasmosis, the other had toxoplasmic retinitis. Both developed multiple bilateral lithiasis with acute renal failure. Normalization of renal function and reduction of calculi size was rapidly achieved after discontinuation of sulfadiazine, hyperhydration, and alkalinization. Bilateral ureteral stents were required in one patient because of anuria.
Literature
1.
Crespo M, Quereda C, Pascual J, Rivera M, Clemente L, Cano T (2000) Patterns of sulfadiazine acute nephrotoxicity. Clin Nephrol 54:68–72PubMed
2.
Portoles J, Torralbo A, Prats D, Blanco J, Barrientos A (1994) Acute renal failure and sulphadiazine crystalluria in kidney transplant. Nephrol Dial Transplant 9:180–181PubMed
3.
Winterborn MH, Mann JR (1973) Anuria due to sulphadiazine. Arch Dis Child 48:915–917PubMed
4.
Sasson JP, Dratch PL, Shortsleeve MJ (1992) Renal US findings in sulfadiazine-induced crystalluria. Radiology 185:739–740PubMed
5.
Kane D, Murphy JM, Keating S, Wilson GF, Mulcahy FM (1996) Renal ultrasonic findings in sulphadiazine-induced renal failure. Br J Radiol 69:925–928PubMed
6.
Becker K, Jablonowski H, Haussinger D (1996) Sulfadiazine-associated nephrotoxicity in patients with the acquired immunodeficiency syndrome. Medicine (Baltimore) 75:185–194
7.
Perazella MA (2003) Drug-induced renal failure: update on new medications and unique mechanisms of nephrotoxicity. Am J Med Sci 325:349–362CrossRefPubMed
8.
Oster S, Hutchison F, McCabe R (1990) Resolution of acute renal failure in toxoplasmic encephalitis despite continuance of sulfadiazine. Rev Infect Dis 12:618–620PubMed
9.
Christin S, Baumelou A, Bahri S, Ben Hmida M, Deray G, Jacobs C (1990) Acute renal failure due to sulfadiazine in patients with AIDS. Nephron 55:233–234PubMed
10.
De Jaureguiberry JP, Reboul P, Vey N, Jaubert D (1992) Acute renal failure caused by sulfadiazine crystalluria in AIDS. An historical resurgent iatrogenic complication. Ann Med Interne (Paris) 143:218–219
11.
Marques LP, Madeira EP, Santos OR (1994) Renal alterations induced by sulfadiazine therapy in an AIDS patients. Clin Nephrol 42:68–69PubMed
12.
Marques LP, Silva MT, Madeira EP, Santos OR (1992) Obstructive renal failure due to therapy with sulfadiazine in an AIDS patient. Nephron 62:361PubMed
13.
Goadsby PJ, Donaghy AJ, Lloyd AR, Wakefield D (1987) Acquired immunodeficiency syndrome (AIDS) and sulfadiazine-associated acute renal failure. Ann Intern Med 107:783–784
14.
Bressollette L, Carlhant D, Bellein V, Morand C, Mottier D, Riche C (1994) Crystalluria induced by sulfadiazine in an AIDS patient. Therapie 49:154–155
15.
Rivera M, Liano F, Fortun J, Fernandez-Lucas M, Ortuno J (1993) Sulfadiazine-induced obstructive renal failure in a patient with acquired immunodeficiency syndrome (AIDS). Nephrol Dial Transplant 8:1183–1184PubMed
16.
Potter JL, Kofron WG (1994) Sulfadiazine/N4-acetylsulfadiazine crystalluria in a patient with the acquired immune deficiency syndrome (AIDS). Clin Chim Acta 230:221–224CrossRefPubMed
17.
Farina LA, Palou Redorta J, Chechile Toniolo G (1995) Reversible acute renal failure due to sulfonamide-induced lithiasis in an AIDS patient. Arch Esp Urol 48:418–419PubMed
18.
Hein R, Brunkhorst R, Thon WF, Schedel I, Schmidt RE (1993) Symptomatic sulfadiazine crystalluria in AIDS patients: a report of two cases. Clin Nephrol 39:254–256PubMed
19.
Diaz F, Collazos J, Mayo J, Martinez E (1996) Sulfadiazine-induced multiple urolithiasis and acute renal failure in a patient with AIDS and Toxoplasma encephalitis. Ann Pharmacother 30:41–42PubMed
20.
Molina JM, Belenfant X, Doco-Lecompte T, Idatte JM, Modai J (1991) Sulfadiazine-induced crystalluria in AIDS patients with toxoplasma encephalitis. Aids 5:587–589PubMed
21.
Simon DI, Brosius FC 3rd, Rothstein DM (1990) Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. Arch Intern Med 150:2379–2384CrossRefPubMed
22.
Farinas MC, Echevarria S, Sampedro I, Gonzalez A, Perez del Molino A, Gonzalez-Macias J (1993) Renal failure due to sulphadiazine in AIDS patients with cerebral toxoplasmosis. J Intern Med 233:365–367PubMed
23.
Carbone LG, Bendixen B, Appel GB (1988) Sulfadiazine-associated obstructive nephropathy occurring in a patient with the acquired immunodeficiency syndrome. Am J Kidney Dis 12:72–75PubMed
24.
Colebunders R, Depraetere K, De Droogh E, Kamper A, Corthout B, Bottiau E (1999) Obstructive nephropathy due to sulfa crystals in two HIV seropositive patients treated with sulfadiazine. JBR-BTR 82:153–154
25.
Kronawitter U, Jakob K, Zoller WG, Rauh G, Goebel FD (1993) Acute kidney failure caused by sulfadiazine stones. A complication of the therapy of toxoplasmosis in AIDS. Dtsch Med Wochenschr 118:1683–1686PubMed
26.
Furrer H, Overbeck J von, Jaeger P, Hess B (1994) Sulfadiazine nephrolithiasis and nephropathy. Schweiz Med Wochenschr 124:2100–2105PubMed
27.
Sequera P de, Albalate M, Hernandez J, Vazquez A, Abad J, Ramiro E, Fernandez Guerrero M, Caramelo C, Casado S, Ortiz A (1996) Acute renal failure due to sulphadiazine crystalluria in AIDS patients. Postgrad Med J 72:557–558PubMed
28.
Sahai J, Heimberger T, Collins K, Kaplowitz L, Polk R (1988) Sulfadiazine-induced crystalluria in a patient with the acquired immunodeficiency syndrome: a reminder. Am J Med 84:791–792
Metadata
Title
Sulfadiazine-induced nephrolithiasis in children
Authors
Charlotte Catalano-Pons
Sophie Bargy
Deborah Schlecht
Marie-Dominique Tabone
George Deschênes
Albert Bensman
Tim Ulinski
Publication date
01-08-2004
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 8/2004
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-004-1519-8

Other articles of this Issue 8/2004

Pediatric Nephrology 8/2004 Go to the issue

Original Article

Effects of pentoxifylline in Adriamycin-induced renal disease in rats

Original Article

Role of p38 MAP kinase pathway in a toxin-induced model of hemolytic uremic syndrome

Clinical quiz

Recurrent vomiting and acute renal failure after HUS: Question

Letter to the Editors

Reply to the letter from J. I. Minguela and R. Ruiz-de-Gauna

Brief Report

An unusual cause of acute renal failure: renal lymphoma

Brief Report

Congenital sodium diarrhea in a neonate presenting as acute renal failure