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Pediatric Nephrology
Published in: Pediatric Nephrology 6/2004

01-06-2004 | Brief Report

Ondansetron for paediatric uraemic pruritus: a case report

Author: Pankaj V. Deshpande

Published in: Pediatric Nephrology | Issue 6/2004

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Abstract

Pruritus, secondary to chronic renal failure, can be an extremely distressing symptom. A 15-year-old girl, in end-stage renal disease, presented with pruritus that did not improve on starting peritoneal dialysis. Despite normalising the calcium, phosphate and parathyroid levels, pruritus worsened and showed no response to antihistamines. She was commenced on ondansetron and showed dramatic improvement. Severe uraemic pruritus is rare, but distressing in children and can improve with ondansetron.
Literature
1.
Mettang T, Pauli-Magnus C, Alscher DM (2002) Uraemic pruritus—new perspectives and insights from recent trials. Nephrol Dial Transplant 17:558–563
2.
Mettang T, Fischer FP, Kuhlmann U (1996) Urämischer pruritus—pathophysiologische and therapeutische konzepte. Dtsch Med Wochenschr 121:1025–1031PubMed
3.
Pauli-Magnus C, Mikus G, Alscher DM, Kirschner T, Nagel W, Gugeler N, Risler T, Berger ED, Kuhlmann U, Mettang T (2000) Naltrexone does not relieve uraemic pruritus: results of a randomised, placebo-controlled crossover-study. J Am Soc Nephrol 11:514–519PubMed
4.
Schwab M, Mikus G, Mettang T, Pauli-Magnus C, Kuhlmann U and Arbeitsgemeinschaft für Pädiatrische Nephrologie (1999) Urämischer Pruritus im Kindes- und Jugendalter. Monatsschr Kinderheilkd 147:232
5.
Massry S, Popovzer MM, Coburn JM, Mokoff DL, Maxwell MH, Kleeman CR (1968) Intractable pruritus as a manifestation of secondary hyperparathyroidism in uraemia. N Engl J Med 279:697–700PubMed
6.
Stahle-Backdahl M, Hagermark O, Lins LE, Torring O, Hillinges M, Johansson O (1989) Experimental and immunohistochemical studies on the possible role of parathyroid hormone in uraemic pruritus. J Intern Med 225:411–415PubMed
7.
Blachley JD, Blankenship DM, Menter A, Parker TF III, Knochel JP (1985) Uraemic pruritus: skin divalent ion content and response to ultraviolet phototherapy. Am J Kidney Dis 5:237–241PubMed
8.
Sakata-Kaneko S, Wakatsuki Y, Matsunaga Y, Usui T, Kita T (2000) Altered Th1/Th2 commitment in human CD4 T cells with ageing. Clin Exp Immunol 120:276–310CrossRef
9.
McHugh SM, Rifkin IR, Deighton J, Wilson AB, Lachmann PJ, Lockwood CM, Ewan PW (1995) The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures. Clin Exp Immunol 99:160–167PubMed
10.
Suthanthiran M, Strom TB (1994) Renal transplantation. N Engl J Med 331:365–376
11.
Davis MP, Frandsen JL, Walsh D, Andersen S, Taylor S (2003) Mirtazapine for pruritus. J Pain Symptom Manage 25:188–191CrossRef
12.
Schworer H, Hartmann H, Ramadori G (1995) Relief of cholestatic pruritus by a novel class of drugs: 5-HT3 receptor antagonists: Effectiveness of ondansetron. Pain 61:33–37CrossRefPubMed
13.
Balaskas EV, Bamihas GI, Karamouzis M, Voyiatzis G, Tourkantonis A (1998) Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients. Nephron 78:395–402CrossRefPubMed
14.
Ashmore SD, Jones CH, Newstead CG, Daly MJ, Chrystyn H (2000) Ondansetron therapy for uremic pruritus in haemodialysis patients. Am J Kidney Dis 35:827–831PubMed
15.
Murphy M, Reaich D, Pai P, Finn P, Carmicheal AJ (2003) A randomised, placebo-controlled, double-blind trial of ondansetron in renal itch. Br J Dermatol 148:314–317CrossRefPubMed
16.
Schworer H, Ramadori G (1993) Treatment of pruritus: a new indication for serotonin type 3 receptor antagonists. Clin Invest 71:659–662
17.
Silverberg NB, Singh A, Laude TA (2001) Cutaneous manifestations of chronic renal failure in children of color. Pediatr Dermatol 18:199–204CrossRefPubMed
18.
Altmeyer P, Kachel HG, Schafer G, Fabinder W (1986) Normalisierung der Urämischen Hautveränderungen nach Nierentransplantation. Hautarzt 37:217–221PubMed
Metadata
Title
Ondansetron for paediatric uraemic pruritus: a case report
Author
Pankaj V. Deshpande
Publication date
01-06-2004
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 6/2004
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-004-1471-7

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