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Open Access 09-01-2023 | Original Article

Risk factors for incomplete resection with pharyngeal endoscopic submucosal dissection and long-term prognosis after resection

Authors: Yoshiki Sakaguchi, Yuki Saito, Mizuo Ando, Masafumi Yoshida, Osamu Fukuoka, Kenya Kobayashi, Dai Kubota, Daisuke Ohki, Hiroya Mizutani, Keiko Niimi, Yosuke Tsuji, Mitsuhiro Fujishiro, Tatsuya Yamasoba

Published in: Surgical Endoscopy | Issue 5/2023

Abstract

Background

Advances in endoscopic imaging technology have led to an increase in detection of superficial pharyngeal squamous carcinoma. Endoscopic submucosal dissection (ESD) has been reported to be effective for the treatment of these lesions, however there is still insufficient evidence on the long-term results of pharyngeal ESD.

Methods

This is a single-center retrospective study of all cases of superficial pharyngeal cancer that underwent ESD as primary treatment between January 2010 and May 2022. A total of 83 lesions in 63 patients were analyzed.

Results

The en bloc resection rate was 100%, and R0 resection rate was 59.0%, with an adverse event rate of 6.0%. During a mean observation period of 1134 days, there were 0 cases of disease-specific metastasis or death. However, the 5-year cumulative incidence of metachronous head and neck cancer after resection was 27.1% and the 5-year overall survival and 10-year overall survival after pharyngeal ESD were 87.0% and 69.6%, respectively. Of the 34 cases with non-R0 resection, local recurrence occurred in 8.8%. Location of lesion (p = 0.011), disparity between demarcation of the lesion with NBI and iodine staining (p = 0.026), and non-effective laryngeal elevation (p = 0.080) were risk factors for non-R0 resection.

Conclusion

Pharyngeal ESD is effective and safe. Further studies are needed to improve and standardize indications and strategies for pharyngeal ESD.

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Title: Risk factors for incomplete resection with pharyngeal endoscopic submucosal dissection and long-term prognosis after resection
Authors: Yoshiki Sakaguchi
Yuki Saito
Mizuo Ando
Masafumi Yoshida
Osamu Fukuoka
Kenya Kobayashi
Dai Kubota
Daisuke Ohki
Hiroya Mizutani
Keiko Niimi
Yosuke Tsuji
Mitsuhiro Fujishiro
Tatsuya Yamasoba
Publication date: 09-01-2023
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 5/2023
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-022-09820-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Risk factors for incomplete resection with pharyngeal endoscopic submucosal dissection and long-term prognosis after resection

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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