Skip to main content
Top
Published in: Surgical Endoscopy 11/2017

01-11-2017

Fluoroscopy-guided gastric peroral endoscopic pyloromyotomy (G-POEM): a more reliable and efficient method for treatment of refractory gastroparesis

Authors: H. B. Xue, H. Z. Fan, X. M. Meng, S. Cristofaro, P. Mekaroonkamol, S. Dacha, L. Y. Li, X. L. Fu, S. H. Zhan, Q. Cai

Published in: Surgical Endoscopy | Issue 11/2017

Login to get access

Abstract

Introduction

Prior studies show promising results of the gastric peroral endoscopic pyloromyotomy (G-POEM) procedure for treatment of refractory gastroparesis. One major technical challenge involved in this procedure is identifying the pyloric muscular ring (PMR). The aim of this study is to establish a reliable method for identification of the PMR during G-POEM.

Methods

Fluoroscopy-guided G-POEM was performed by placing an endoclip at the 9 to 11’o clock position at the pylorus for identification of PMR. Conventional G-POEM was performed by observation of blue colored mucosa at the pylorus area as an indirect marker for PMR. The degree of the PMR identification was graded into well identified, identified, and not identified based on the appearance of the PMR. Procedure times were accurately documented. Gastroparesis cardinal symptoms index and gastric emptying scintigraphy were evaluated before and after the procedure.

Results

Fourteen patients were studied, seven underwent fluoroscopy-guided G-POEM, and seven patients underwent conventional G-POEM. All procedures achieved technical success and no adverse events occurred. In the seven patients who underwent fluoroscopy-guided G-POEM, the PMR was well identified in four patients and identified in three patients. In the seven patients who underwent conventional G-POEM, the PMR was identified in four patients and not identified in three patients. The average time to complete the fluoroscopy-guided G-POEM was significantly shorter than that of the conventional G-POEM.

Conclusions

Fluoroscopy-guided G-POEM by placement of an endoclip at the pylorus was a reliable and safe method to direct the orientation of the submucosal tunnel, to facilitate the location of the PMR, and to shorten the procedure time.
Appendix
Available only for authorised users
Literature
1.
go back to reference Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L, American College of G (2013) Clinical guideline: management of gastroparesis. Am J Gastroenterol 108:18–37 (quiz 38) CrossRefPubMed Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L, American College of G (2013) Clinical guideline: management of gastroparesis. Am J Gastroenterol 108:18–37 (quiz 38) CrossRefPubMed
3.
go back to reference Gonzalez JM, Vanbiervliet G, Vitton V, Benezech A, Lestelle V, Grimaud JC, Barthet M (2015) First European human gastric peroral endoscopic myotomy, for treatment of refractory gastroparesis. Endoscopy 47(Suppl 1 UCTN):E135–E136PubMed Gonzalez JM, Vanbiervliet G, Vitton V, Benezech A, Lestelle V, Grimaud JC, Barthet M (2015) First European human gastric peroral endoscopic myotomy, for treatment of refractory gastroparesis. Endoscopy 47(Suppl 1 UCTN):E135–E136PubMed
4.
5.
go back to reference Clarke JO, Snape WJ Jr (2015) Pyloric sphincter therapy: botulinum toxin, stents, and pyloromyotomy. Gastroenterol Clin North Am 44:127–136CrossRefPubMed Clarke JO, Snape WJ Jr (2015) Pyloric sphincter therapy: botulinum toxin, stents, and pyloromyotomy. Gastroenterol Clin North Am 44:127–136CrossRefPubMed
6.
go back to reference Hibbard ML, Dunst CM, Swanstrom LL (2011) Laparoscopic and endoscopic pyloroplasty for gastroparesis results in sustained symptom improvement. J Gastrointest Surg 15:1513–1519CrossRefPubMed Hibbard ML, Dunst CM, Swanstrom LL (2011) Laparoscopic and endoscopic pyloroplasty for gastroparesis results in sustained symptom improvement. J Gastrointest Surg 15:1513–1519CrossRefPubMed
7.
go back to reference Jones MP, Maganti K (2003) A systematic review of surgical therapy for gastroparesis. Am J Gastroenterol 98:2122–2129CrossRefPubMed Jones MP, Maganti K (2003) A systematic review of surgical therapy for gastroparesis. Am J Gastroenterol 98:2122–2129CrossRefPubMed
8.
go back to reference Toro JP, Lytle NW, Patel AD, Davis SS Jr, Christie JA, Waring JP, Sweeney JF, Lin E (2014) Efficacy of laparoscopic pyloroplasty for the treatment of gastroparesis. J Am Coll Surg 218:652–660CrossRefPubMed Toro JP, Lytle NW, Patel AD, Davis SS Jr, Christie JA, Waring JP, Sweeney JF, Lin E (2014) Efficacy of laparoscopic pyloroplasty for the treatment of gastroparesis. J Am Coll Surg 218:652–660CrossRefPubMed
9.
go back to reference Khashab MA, Stein E, Clarke JO, Saxena P, Kumbhari V, Chander Roland B, Kalloo AN, Stavropoulos S, Pasricha P, Inoue H (2013) Gastric peroral endoscopic myotomy for refractory gastroparesis: first human endoscopic pyloromyotomy (with video). Gastrointest Endosc 78:764–768CrossRefPubMed Khashab MA, Stein E, Clarke JO, Saxena P, Kumbhari V, Chander Roland B, Kalloo AN, Stavropoulos S, Pasricha P, Inoue H (2013) Gastric peroral endoscopic myotomy for refractory gastroparesis: first human endoscopic pyloromyotomy (with video). Gastrointest Endosc 78:764–768CrossRefPubMed
10.
go back to reference Khashab MA, Ngamruengphong S, Carr-Locke D, Bapaye A, Benias PC, Serouya S, Dorwat S, Chaves DM, Artifon E, de Moura EG, Kumbhari V, Haito Chavez Y, Bukhari M, Hajiyeva G, Ismail A, Chen YI, Chung H (2016) Gastric peroral endoscopic myotomy for refractory gastroparesis: results from the first multicenter study on endoscopic pyloromyotomy (with video). Gastrointest Endosc 25:30332–30337 Khashab MA, Ngamruengphong S, Carr-Locke D, Bapaye A, Benias PC, Serouya S, Dorwat S, Chaves DM, Artifon E, de Moura EG, Kumbhari V, Haito Chavez Y, Bukhari M, Hajiyeva G, Ismail A, Chen YI, Chung H (2016) Gastric peroral endoscopic myotomy for refractory gastroparesis: results from the first multicenter study on endoscopic pyloromyotomy (with video). Gastrointest Endosc 25:30332–30337
11.
go back to reference Shlomovitz E, Pescarus R, Cassera MA, Sharata AM, Reavis KM, Dunst CM, Swanstrom LL (2015) Early human experience with per-oral endoscopic pyloromyotomy (POP). Surg Endosc 29:543–551CrossRefPubMed Shlomovitz E, Pescarus R, Cassera MA, Sharata AM, Reavis KM, Dunst CM, Swanstrom LL (2015) Early human experience with per-oral endoscopic pyloromyotomy (POP). Surg Endosc 29:543–551CrossRefPubMed
12.
go back to reference Gonzalez JM, Lestelle V, Benezech A, Cohen J, Vitton V, Grimaud JC, Barthet M (2016) Gastric per-oral endoscopic myotomy with antro-pyloro-myotomy in the treatment of refractory gastroparesis: clinical experience with follow-up and scintigraphic evaluation (with video). Gastrointest Endosc 28:30435–30437 Gonzalez JM, Lestelle V, Benezech A, Cohen J, Vitton V, Grimaud JC, Barthet M (2016) Gastric per-oral endoscopic myotomy with antro-pyloro-myotomy in the treatment of refractory gastroparesis: clinical experience with follow-up and scintigraphic evaluation (with video). Gastrointest Endosc 28:30435–30437
13.
go back to reference Mekaroonkamol P, Li LY, Dacha S, Xu Y, Keilin SD, Willingham FF, Cai Q (2016) Gastric peroral endoscopic pyloromyotomy (G-POEM) as a salvage therapy for refractory gastroparesis: a case series of different subtypes. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc 28(8):1272–1277CrossRef Mekaroonkamol P, Li LY, Dacha S, Xu Y, Keilin SD, Willingham FF, Cai Q (2016) Gastric peroral endoscopic pyloromyotomy (G-POEM) as a salvage therapy for refractory gastroparesis: a case series of different subtypes. Neurogastroenterol Motil Off J Eur Gastrointest Motil Soc 28(8):1272–1277CrossRef
14.
go back to reference Chaves DM, de Moura EG, Mestieri LH, Artifon EL, Sakai P (2014) Endoscopic pyloromyotomy via a gastric submucosal tunnel dissection for the treatment of gastroparesis after surgical vagal lesion. Gastrointest Endosc 80:164CrossRefPubMed Chaves DM, de Moura EG, Mestieri LH, Artifon EL, Sakai P (2014) Endoscopic pyloromyotomy via a gastric submucosal tunnel dissection for the treatment of gastroparesis after surgical vagal lesion. Gastrointest Endosc 80:164CrossRefPubMed
15.
go back to reference Chung H, Dallemagne B, Perretta S, Lee SK, Shin SK, Park JC, Marescaux J, Lee YC (2014) Endoscopic pyloromyotomy for postesophagectomy gastric outlet obstruction. Endoscopy 46(Suppl 1 UCTN):E345–E346PubMed Chung H, Dallemagne B, Perretta S, Lee SK, Shin SK, Park JC, Marescaux J, Lee YC (2014) Endoscopic pyloromyotomy for postesophagectomy gastric outlet obstruction. Endoscopy 46(Suppl 1 UCTN):E345–E346PubMed
16.
go back to reference Bapaye A, Dubale N, Pujari R, Kulkarni A, Jajoo Naval R, Vyas V, Mahadik M (2015) Peroral endoscopic pyloromyotomy for delayed postoperative gastroparesis. Endoscopy 47:E581–E582CrossRefPubMed Bapaye A, Dubale N, Pujari R, Kulkarni A, Jajoo Naval R, Vyas V, Mahadik M (2015) Peroral endoscopic pyloromyotomy for delayed postoperative gastroparesis. Endoscopy 47:E581–E582CrossRefPubMed
17.
go back to reference Minami H, Inoue H, Haji A, Isomoto H, Urabe S, Hashiguchi K, Matsushima K, Akazawa Y, Yamaguchi N, Ohnita K, Takeshima F, Nakao K (2015) Per-oral endoscopic myotomy: emerging indications and evolving techniques. Dig Endosc 27:175–181CrossRefPubMed Minami H, Inoue H, Haji A, Isomoto H, Urabe S, Hashiguchi K, Matsushima K, Akazawa Y, Yamaguchi N, Ohnita K, Takeshima F, Nakao K (2015) Per-oral endoscopic myotomy: emerging indications and evolving techniques. Dig Endosc 27:175–181CrossRefPubMed
18.
go back to reference Jung Y, Lee J, Gromski MA, Kato M, Rodriguez S, Chuttani R, Matthes K (2015) Assessment of the length of myotomy in peroral endoscopic pyloromyotomy (G-POEM) using a submucosal tunnel technique (video). Surg Endosc 29:2377–2384CrossRefPubMed Jung Y, Lee J, Gromski MA, Kato M, Rodriguez S, Chuttani R, Matthes K (2015) Assessment of the length of myotomy in peroral endoscopic pyloromyotomy (G-POEM) using a submucosal tunnel technique (video). Surg Endosc 29:2377–2384CrossRefPubMed
19.
go back to reference Yang CW, Wang BY, Chou KC, Yen HH, Chen YY (2015) Acute gastric mucosal ischemic ulcer: a rare adverse result of peroral endoscopic myotomy. Endoscopy 47(Suppl 1):E614–E615PubMed Yang CW, Wang BY, Chou KC, Yen HH, Chen YY (2015) Acute gastric mucosal ischemic ulcer: a rare adverse result of peroral endoscopic myotomy. Endoscopy 47(Suppl 1):E614–E615PubMed
20.
go back to reference Louazon T, Rivory J, Roman S, Mion F, Ponchon T, Pioche M (2016) Temporary dumping syndrome after gastric peroral endoscopic myotomy: should we control the glycemia? Endoscopy 48(Suppl 1 UCTN):E10–E11PubMed Louazon T, Rivory J, Roman S, Mion F, Ponchon T, Pioche M (2016) Temporary dumping syndrome after gastric peroral endoscopic myotomy: should we control the glycemia? Endoscopy 48(Suppl 1 UCTN):E10–E11PubMed
21.
go back to reference Mekaroonkamol P, Li L, Cai Q (2017) The role of pyloric manometry in gastric per-oral endoscopic pyloromyotomy (G-POEM): response to Jacques et al. Neurogastroenterol Motil. doi:10.1111/nmo.12949 PubMed Mekaroonkamol P, Li L, Cai Q (2017) The role of pyloric manometry in gastric per-oral endoscopic pyloromyotomy (G-POEM): response to Jacques et al. Neurogastroenterol Motil. doi:10.​1111/​nmo.​12949 PubMed
22.
go back to reference Dacha S, Mekaroonkamol P, Li L, Shahnavaz N, Sakaria S, Keilin S, Willingham F, Christie, J, Cai Q (2017) Outcomes and quality of life assessment after gastric per oral endoscopic pyloromyotomy. Gastrointest Endosc. doi:10.1016/j.gie.2017.01.031 PubMed Dacha S, Mekaroonkamol P, Li L, Shahnavaz N, Sakaria S, Keilin S, Willingham F, Christie, J, Cai Q (2017) Outcomes and quality of life assessment after gastric per oral endoscopic pyloromyotomy. Gastrointest Endosc. doi:10.​1016/​j.​gie.​2017.​01.​031 PubMed
Metadata
Title
Fluoroscopy-guided gastric peroral endoscopic pyloromyotomy (G-POEM): a more reliable and efficient method for treatment of refractory gastroparesis
Authors
H. B. Xue
H. Z. Fan
X. M. Meng
S. Cristofaro
P. Mekaroonkamol
S. Dacha
L. Y. Li
X. L. Fu
S. H. Zhan
Q. Cai
Publication date
01-11-2017
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 11/2017
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-017-5524-y

Other articles of this Issue 11/2017

Surgical Endoscopy 11/2017 Go to the issue