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Published in: Surgical Endoscopy 8/2017

01-08-2017

Cost analysis of laparoendoscopic rendezvous versus preoperative ERCP and laparoscopic cholecystectomy in the management of cholecystocholedocholithiasis

Authors: Aldo Garbarini, Dario Reggio, Simone Arolfo, Marco Bruno, Roberto Passera, Giorgia Catalano, Claudio Barletti, Mauro Salizzoni, Mario Morino, Luca Petruzzelli, Alberto Arezzo

Published in: Surgical Endoscopy | Issue 8/2017

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Abstract

Background

Evidence from controlled trials and meta-analyses suggests that laparoendoscopic rendezvous (LERV) is preferable to sequential treatment in the management of common bile duct stones.

Materials and methods

With this retrospective analysis of a prospective database that included consecutive patients treated for cholecystocholedocholithiasis at our institution between January 2007 and July 2015, we compared LERV with sequential treatment. The primary endpoint was global cost, defined as the cost/patient/hospital stay, and the secondary end points were efficacy and morbidity. Fisher’s exact test or Mann–Whitney test was used.

Results

Of a total of 249 consecutive patients, 143 underwent LERV (group A) and 106 a two-stage procedure (group B). Based on an average cost of €613 for 1 day of hospital stay in the General Surgery Department, the overall median cost of treatment was €6403 for group A and €8194 for group B (p < 0.001). Operative time was significantly shorter (p < 0.001), and length of hospital stay was significantly longer for group B (p < 0.001). No mortality in either group was observed. The postoperative complications rate was significantly higher in group B than in group A (24.5 vs. 10.5%; p = 0.003). No significant difference in the postoperative pancreatitis rate or the number of patients with increased serum amylase at 24 h was observed in either group.

Conclusion

Our study suggests that LERV is preferable to sequential treatment not only in terms of less morbidity, but also of lower costs accrued by a shorter hospital stay. However, the longer operative time raises multiple organizational issues in the coordination of surgery and endoscopy services.
Literature
1.
go back to reference Menezes N, Marso LP, Debeaux AC, Muir IM, Auld CD (2000) Prospective analysis of a scoring system to predict choledocholithiasis. Br J Surg 87:1176–1181CrossRefPubMed Menezes N, Marso LP, Debeaux AC, Muir IM, Auld CD (2000) Prospective analysis of a scoring system to predict choledocholithiasis. Br J Surg 87:1176–1181CrossRefPubMed
2.
go back to reference Collins C, Maguire D, Ireland A, Fitzgerald E, O’Sullivan GC (2004) A prospective study of common bile duct calculi in patients undergoing laparoscopic cholecystectomy: natural history of choledocholithiasis revisited. Ann Surg 239:28–33CrossRefPubMedPubMedCentral Collins C, Maguire D, Ireland A, Fitzgerald E, O’Sullivan GC (2004) A prospective study of common bile duct calculi in patients undergoing laparoscopic cholecystectomy: natural history of choledocholithiasis revisited. Ann Surg 239:28–33CrossRefPubMedPubMedCentral
3.
go back to reference NIH Consensus Conference (1993) Gallstones and laparoscopic cholecystectomy. JAMA 269:1018–1024CrossRef NIH Consensus Conference (1993) Gallstones and laparoscopic cholecystectomy. JAMA 269:1018–1024CrossRef
4.
go back to reference Perniceni T, Slim K (2001) Quelles sont les indications vlidées de la coelioscopie en chirurgie digestive. Gastroenterol Clin Biol 25:B57–B70PubMed Perniceni T, Slim K (2001) Quelles sont les indications vlidées de la coelioscopie en chirurgie digestive. Gastroenterol Clin Biol 25:B57–B70PubMed
5.
go back to reference Martin DJ, Vernon DR, Toouli J (2013) Surgical versus endoscopic treatment of bile duct stones. Cochrane Database Syst Rev 9:CD003327. Martin DJ, Vernon DR, Toouli J (2013) Surgical versus endoscopic treatment of bile duct stones. Cochrane Database Syst Rev 9:CD003327.
6.
go back to reference Cuschieri A, Lezoche E, Morino M, Croce E, Lacy A, Toouli J, Faggioni A, Ribeiro M, Jakimowicz J, Visa J, Hanna GB (1999) E.A.E.S. multicenter prospective randomized trial comparing two-stage vs single-stage management of patients with gallstone disease and ductal calculi. Surg Endosc 13:952–957CrossRefPubMed Cuschieri A, Lezoche E, Morino M, Croce E, Lacy A, Toouli J, Faggioni A, Ribeiro M, Jakimowicz J, Visa J, Hanna GB (1999) E.A.E.S. multicenter prospective randomized trial comparing two-stage vs single-stage management of patients with gallstone disease and ductal calculi. Surg Endosc 13:952–957CrossRefPubMed
7.
go back to reference Carr-Locke DL et al (2002) Therapeutic role of ERCP in the management of suspected common bile duct stones. Gastrointest Endosc 56:170–174CrossRef Carr-Locke DL et al (2002) Therapeutic role of ERCP in the management of suspected common bile duct stones. Gastrointest Endosc 56:170–174CrossRef
8.
go back to reference Cavina E, Franceschi M, Sidoti F, Goletti O, Buccianti P, Chiarugi M (1998) Laparoendoscopic, “rendezvous”: a new technique in the choledocholithiasis treatment. Hepatogastroenterology 45:1430–1435PubMed Cavina E, Franceschi M, Sidoti F, Goletti O, Buccianti P, Chiarugi M (1998) Laparoendoscopic, “rendezvous”: a new technique in the choledocholithiasis treatment. Hepatogastroenterology 45:1430–1435PubMed
9.
go back to reference Lella F, Bagnolo F, Rebuffat C, Scalambra M, Bonassi U, Colombo E (2006) Use of laparoscopic-endoscopic approach, the so-called rendezvous technique in cholecystocholedocholithiasys. A valid method in cases with patient-related risk factor for post-ERCP pancreatitis. Surg Endosc 20:419–423CrossRefPubMed Lella F, Bagnolo F, Rebuffat C, Scalambra M, Bonassi U, Colombo E (2006) Use of laparoscopic-endoscopic approach, the so-called rendezvous technique in cholecystocholedocholithiasys. A valid method in cases with patient-related risk factor for post-ERCP pancreatitis. Surg Endosc 20:419–423CrossRefPubMed
10.
go back to reference Morino M, Baracchi F, Miglietta C, Furlan N, Ragona R, Garbarini A (2006) Preoperative endoscopic sphincterotomy versus laparoendoscopic rendezvous in patients with gallbladder and bile duct stones. Ann Surg 244:889–896CrossRefPubMedPubMedCentral Morino M, Baracchi F, Miglietta C, Furlan N, Ragona R, Garbarini A (2006) Preoperative endoscopic sphincterotomy versus laparoendoscopic rendezvous in patients with gallbladder and bile duct stones. Ann Surg 244:889–896CrossRefPubMedPubMedCentral
11.
go back to reference Rabago LR, Vicente C, Soler F, Delgado M, Moral I, Guerra I, Castro JL, Quintanilla E, Romeo J, Llorente R, Vazquez Echarri J, Martinez-Veiga JL, Gea F (2006) Two-stage treatment with preoperative endoscopic retrograde cholangiopancreatography (ERCP) compared with single-stage treatment with intraoperative ERCP for patients with symptomatic cholelithiasis with possible choledocholithiasis. Endoscopy 38:779–786CrossRefPubMed Rabago LR, Vicente C, Soler F, Delgado M, Moral I, Guerra I, Castro JL, Quintanilla E, Romeo J, Llorente R, Vazquez Echarri J, Martinez-Veiga JL, Gea F (2006) Two-stage treatment with preoperative endoscopic retrograde cholangiopancreatography (ERCP) compared with single-stage treatment with intraoperative ERCP for patients with symptomatic cholelithiasis with possible choledocholithiasis. Endoscopy 38:779–786CrossRefPubMed
12.
go back to reference Tsovaras G, Baloyiannis I, Zachari E, Symeonidis D, Zacharoulis D, Kapsoritakis A, Paroutoglou G, Potamianos S (2012) Laparoendoscopic rendezvous versus preoperative ERCP and laparoendoscopic cholecystectomy for the management of cholecystocholedicholithiasis: interim analysis of a controlled randomized trial. Ann Surg 255:435–439CrossRef Tsovaras G, Baloyiannis I, Zachari E, Symeonidis D, Zacharoulis D, Kapsoritakis A, Paroutoglou G, Potamianos S (2012) Laparoendoscopic rendezvous versus preoperative ERCP and laparoendoscopic cholecystectomy for the management of cholecystocholedicholithiasis: interim analysis of a controlled randomized trial. Ann Surg 255:435–439CrossRef
13.
go back to reference Arezzo A, Vettoretto N, Famiglietti F, Moja L, Morino M (2013) Laparoendoscopic rendezvous reduces perioperative morbidity and risk of pancreatitis. Surg Endosc 27:1055–1060CrossRefPubMed Arezzo A, Vettoretto N, Famiglietti F, Moja L, Morino M (2013) Laparoendoscopic rendezvous reduces perioperative morbidity and risk of pancreatitis. Surg Endosc 27:1055–1060CrossRefPubMed
14.
go back to reference La Greca G, Barbagallo F, Sofia M, Latteri S, Rusello D (2010) Simultaneous laparoendoscopic rendezvous for the treatment of cholecystocholedocholithiasis. Surg Endosc 24:769–780CrossRef La Greca G, Barbagallo F, Sofia M, Latteri S, Rusello D (2010) Simultaneous laparoendoscopic rendezvous for the treatment of cholecystocholedocholithiasis. Surg Endosc 24:769–780CrossRef
15.
go back to reference De Palma GD, Angrisani L, Lorenzo M, Di Matteo E, Catanzano C, Persico G, Tesauro B (1996) Laparoscopic cholecystectomy (LC), intraoperative endoscopic sphincterotomy (ES), and common bile duct stones (CBDS) extraction for management of patient with cholecystocholedocholithiasis. Surg Endosc 10:649–652CrossRefPubMed De Palma GD, Angrisani L, Lorenzo M, Di Matteo E, Catanzano C, Persico G, Tesauro B (1996) Laparoscopic cholecystectomy (LC), intraoperative endoscopic sphincterotomy (ES), and common bile duct stones (CBDS) extraction for management of patient with cholecystocholedocholithiasis. Surg Endosc 10:649–652CrossRefPubMed
16.
go back to reference Moroni J, Haurie JP, Judchak I, Fuster S (1999) Single-stage laparoscopic and endoscopic treatment for choledocholithiasis: a novel approach. J Laparoendosc Adv Surg Tech A 9:69–74CrossRefPubMed Moroni J, Haurie JP, Judchak I, Fuster S (1999) Single-stage laparoscopic and endoscopic treatment for choledocholithiasis: a novel approach. J Laparoendosc Adv Surg Tech A 9:69–74CrossRefPubMed
17.
go back to reference Tricarico A, Cione G, Sozio M, Di Palo P, Bottino V, Tricarico T, Tartatglio A, Iazzetta I, Sessa E, Mosca S, De Nucci C, Falco P (2002) Endolaparoscopic rendezvous treatment: a satisfying therapeutic choice for cholecystocholedocolithiasis. Surg Endosc 16:711–713CrossRefPubMed Tricarico A, Cione G, Sozio M, Di Palo P, Bottino V, Tricarico T, Tartatglio A, Iazzetta I, Sessa E, Mosca S, De Nucci C, Falco P (2002) Endolaparoscopic rendezvous treatment: a satisfying therapeutic choice for cholecystocholedocolithiasis. Surg Endosc 16:711–713CrossRefPubMed
18.
go back to reference Sanjay P, Kulli C, Polignano FM, Tait IS (2010) Optimal surgical technique, use of intra-operative cholangiography, and management of acute gallbladder disease: the results of a nation-widde survey in the UK and Ireland. Ann R Coll Surg Engl 92:302–306CrossRefPubMedPubMedCentral Sanjay P, Kulli C, Polignano FM, Tait IS (2010) Optimal surgical technique, use of intra-operative cholangiography, and management of acute gallbladder disease: the results of a nation-widde survey in the UK and Ireland. Ann R Coll Surg Engl 92:302–306CrossRefPubMedPubMedCentral
19.
go back to reference Clayton E, Connor S, Alexakis N, Leandros E (2006) Metaanalysis of endoscopy and surgery versus surgery alone for common bile duct stones with the gallbladder in situ. Br J Surg 93:1185–1191CrossRefPubMed Clayton E, Connor S, Alexakis N, Leandros E (2006) Metaanalysis of endoscopy and surgery versus surgery alone for common bile duct stones with the gallbladder in situ. Br J Surg 93:1185–1191CrossRefPubMed
20.
21.
go back to reference Saccomani G, Durante V, Magnolia MR, Ghezzo L, Lombezzi R, Esercizio L, Stella M, Arezzo A (2005) Combined endoscopic treatment for cholelithiasis associated with choledocholithiasis. Surg Endosc 19:910–914CrossRefPubMed Saccomani G, Durante V, Magnolia MR, Ghezzo L, Lombezzi R, Esercizio L, Stella M, Arezzo A (2005) Combined endoscopic treatment for cholelithiasis associated with choledocholithiasis. Surg Endosc 19:910–914CrossRefPubMed
23.
go back to reference Ding X, Zhang F, Wang Y (2015) Risk factors for post-ERCP pancreatitis: a systematic review and meta-analysis. Surgeon 13:218–229CrossRefPubMed Ding X, Zhang F, Wang Y (2015) Risk factors for post-ERCP pancreatitis: a systematic review and meta-analysis. Surgeon 13:218–229CrossRefPubMed
24.
go back to reference La Greca G, Barbagallo F, Di Blasi M, Chisari A, Lombardo R, Bonaccorso R, Latteri S, Di Stefano A, Russello D (2008) Laparoendoscopic, “rendezvous” to treat cholecystocholedocolithiasis: effective, safe and simplifies the endoscopist’s work. World J Gastroenterol 14:2844–2850CrossRefPubMedPubMedCentral La Greca G, Barbagallo F, Di Blasi M, Chisari A, Lombardo R, Bonaccorso R, Latteri S, Di Stefano A, Russello D (2008) Laparoendoscopic, “rendezvous” to treat cholecystocholedocolithiasis: effective, safe and simplifies the endoscopist’s work. World J Gastroenterol 14:2844–2850CrossRefPubMedPubMedCentral
25.
go back to reference Williams GL, Vellacott KD (2002) Selective operative cholangiography and perioperative endoscopic retrograde cholangiopancreatography (ERCP) during laparoscopic cholecystectomy: a viable option for choledocholithiasis. Surg Endosc 16:465–467CrossRefPubMed Williams GL, Vellacott KD (2002) Selective operative cholangiography and perioperative endoscopic retrograde cholangiopancreatography (ERCP) during laparoscopic cholecystectomy: a viable option for choledocholithiasis. Surg Endosc 16:465–467CrossRefPubMed
Metadata
Title
Cost analysis of laparoendoscopic rendezvous versus preoperative ERCP and laparoscopic cholecystectomy in the management of cholecystocholedocholithiasis
Authors
Aldo Garbarini
Dario Reggio
Simone Arolfo
Marco Bruno
Roberto Passera
Giorgia Catalano
Claudio Barletti
Mauro Salizzoni
Mario Morino
Luca Petruzzelli
Alberto Arezzo
Publication date
01-08-2017
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 8/2017
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-016-5361-4

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