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Surgical Endoscopy

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01-11-2015

Serum value of procalcitonin as a marker of intestinal damages: type, extension, and prognosis

Authors: C. Cosse, C. Sabbagh, F. Browet, F. Mauvais, L. Rebibo, E. Zogheib, D. Chatelain, S. Kamel, J. M. Regimbeau

Published in: Surgical Endoscopy | Issue 11/2015

Abstract

Background

Ischemic and necrotic damages are complications of digestive diseases and require emergency management. Nevertheless, the decision to surgically manage could be delayed because of no sufficiently preoperative accurate marker of ischemia diagnosis, extension, and prognosis.

Methods

The aim of this study was to assess the predictive value of serum procalcitonin (PCT) levels for diagnosing intestinal necrotic damages, their extension, and their prognosis in patients with ischemic disease including ischemic colitis and mesenteric infarction by a gray zone approach. Between January 2007 to June 2014, 128 patients with ischemic colitis and mesenteric infarction (codes K55.0 and K51.9) were operated, for whom data on PCT were available. We perform a retrospective, multicenter review of their medical records. Patients were divided into subgroups: ischemia (ID group) versus necrosis (ND group); the extension [focal (FD) vs. extended (ED)] and the vital status [deceased (D) vs. alive (A)].

Results

PCT levels were higher in the ND (n = 94; p = 0.009); ED (n = 100; p = 0.02); and D (n = 70; p = 0.0003) groups. With a gray zone approach, the predictive thresholds were (i) for necrosis 2.473 ng/mL, (ii) for extension 3.884 ng/mL, and (iii) for mortality 7.87 ng/mL.

Conclusion

In our population, PCT could be used as a marker of necrosis; especially in case of extended damages and reflects the patient’s prognosis.

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Title: Serum value of procalcitonin as a marker of intestinal damages: type, extension, and prognosis
Authors: C. Cosse
C. Sabbagh
F. Browet
F. Mauvais
L. Rebibo
E. Zogheib
D. Chatelain
S. Kamel
J. M. Regimbeau
Publication date: 01-11-2015
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 11/2015
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-014-4038-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Serum value of procalcitonin as a marker of intestinal damages: type, extension, and prognosis

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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