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Published in: Surgical Endoscopy 2/2015

01-02-2015

Thromboembolic events in bariatric surgery: a large multi-institutional referral center experience

Authors: Mohammad H. Jamal, Ricard Corcelles, Hideharu Shimizu, Mathew Kroh, Fernando M. Safdie, Raul Rosenthal, Stacy A. Brethauer, Philip R. Schauer

Published in: Surgical Endoscopy | Issue 2/2015

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Abstract

Introduction

The risk of venous thromboembolic (VTE) events is increased in patients undergoing bariatric surgery. Population studies examining VTE rates after bariatric surgery often lack details and uniformity regarding the prophylactic regimens used. The aim of this study was to determine the incidence of VTE in patients undergoing laparoscopic bariatric surgery.

Methods

Database searches from Cleveland Clinic bariatric surgery programs in Cleveland, OH, and Weston, FL, were conducted from January 2005 to January 2013. Mechanical and chemical prophylaxes were provided for all patients as per protocol. Data on age, gender, body mass index (BMI), interval between procedure and VTE, inpatient versus outpatient status, anticoagulation prophylaxis, type of surgery and mortality were collected.

Results

A total of 4,293 patients underwent primary or revisional bariatric surgery during this 8-year time period. VTE events were identified in 57 patients (1.3 %). Pulmonary embolism (PE) was identified in 39 patients (0.9 %), and 15 of these patients had negative duplex studies of the lower extremities. Deep venous thrombosis only was identified in 18 patients (0.4 %). VTE rates for gastric bypass (n = 2,945), sleeve gastrectomy (n = 709), gastric banding (n = 467) and revisional procedures (n = 171) were 1.1, 2.9, 0.2 and 6.4 %, respectively. Eight patients had VTE diagnosed during their inpatient stay. The mean time to VTE diagnosis after surgery was 24 days. Seventeen patients who developed VTE had been prescribed extended prophylaxis for 2–4 weeks after discharge. There was only one VTE-related mortality from PE reported in this cohort (0.02 %). Univariate and multivariate analyses revealed age, BMI, open and revisional surgery as predictive of VTE (p < 0.05).

Conclusion

The risk of VTE among morbidly obese patients undergoing bariatric surgery is persistent despite use of laparoscopy and aggressive prophylactic anticoagulation policy. Patients with advanced age, higher BMI and those undergoing open or revisional surgery are at higher risk of postoperative VTE.
Literature
1.
go back to reference Brotman DJ, Shihab HM, Prakasa KR et al (2013) Pharmacologic and mechanical strategies for preventing venous thromboembolism after bariatric surgery: a systematic review and meta-analysis. JAMA Surg 148(7):675–686PubMedCrossRef Brotman DJ, Shihab HM, Prakasa KR et al (2013) Pharmacologic and mechanical strategies for preventing venous thromboembolism after bariatric surgery: a systematic review and meta-analysis. JAMA Surg 148(7):675–686PubMedCrossRef
2.
go back to reference Borch KH, Braekkan SK, Mathiesen EB et al (2009) Abdominal obesity is essential for the risk of venous thromboembolism in the metabolic syndrome: the tromso study. J Thromb Haemost 7(5):739–745PubMedCrossRef Borch KH, Braekkan SK, Mathiesen EB et al (2009) Abdominal obesity is essential for the risk of venous thromboembolism in the metabolic syndrome: the tromso study. J Thromb Haemost 7(5):739–745PubMedCrossRef
3.
go back to reference Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW (2008) Cardiovascular risk factors and venous thromboembolism: a meta-analysis. Circulation 117(1):93–102PubMedCrossRef Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW (2008) Cardiovascular risk factors and venous thromboembolism: a meta-analysis. Circulation 117(1):93–102PubMedCrossRef
4.
go back to reference Finks JF, English WJ, Carlin AM et al (2012) Predicting risk for venous thromboembolism with bariatric surgery: results from the Michigan bariatric surgery collaborative. Ann Surg 255(6):1100–1104PubMedCrossRef Finks JF, English WJ, Carlin AM et al (2012) Predicting risk for venous thromboembolism with bariatric surgery: results from the Michigan bariatric surgery collaborative. Ann Surg 255(6):1100–1104PubMedCrossRef
5.
go back to reference Carmody BJ, Sugerman HJ, Kellum JM et al (2006) Pulmonary embolism complicating bariatric surgery: detailed analysis of a single institution’s 24-year experience. J Am Coll Surg 203(6):831–837PubMedCrossRef Carmody BJ, Sugerman HJ, Kellum JM et al (2006) Pulmonary embolism complicating bariatric surgery: detailed analysis of a single institution’s 24-year experience. J Am Coll Surg 203(6):831–837PubMedCrossRef
6.
go back to reference Birkmeyer NJ, Finks JF, Carlin AM et al (2012) Comparative effectiveness of unfractionated and low-molecular-weight heparin for prevention of venous thromboembolism following bariatric surgery. Arch Surg 147(11):994–998PubMedCrossRef Birkmeyer NJ, Finks JF, Carlin AM et al (2012) Comparative effectiveness of unfractionated and low-molecular-weight heparin for prevention of venous thromboembolism following bariatric surgery. Arch Surg 147(11):994–998PubMedCrossRef
7.
go back to reference Morino M, Toppino M, Forestieri P, Angrisani L, Allaix ME, Scopinaro N (2007) Mortality after bariatric surgery: analysis of 13, 871 morbidly obese patients from a national registry. Ann Surg 246(6):1002–1007 discussion 1007-9PubMedCrossRef Morino M, Toppino M, Forestieri P, Angrisani L, Allaix ME, Scopinaro N (2007) Mortality after bariatric surgery: analysis of 13, 871 morbidly obese patients from a national registry. Ann Surg 246(6):1002–1007 discussion 1007-9PubMedCrossRef
8.
go back to reference Goldfeder LB, Ren CJ, Gill JR (2006) Fatal complications of bariatric surgery. Obes Surg 16(8):1050–1056PubMedCrossRef Goldfeder LB, Ren CJ, Gill JR (2006) Fatal complications of bariatric surgery. Obes Surg 16(8):1050–1056PubMedCrossRef
9.
go back to reference Mechanick JI, Youdim A, Jones DB et al (2013) Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient–2013 update: cosponsored by American association of clinical endocrinologists, the obesity society, and American society for metabolic & bariatric surgery. Obesity (Silver Spring) 21(Suppl 1):S1–S27CrossRef Mechanick JI, Youdim A, Jones DB et al (2013) Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient–2013 update: cosponsored by American association of clinical endocrinologists, the obesity society, and American society for metabolic & bariatric surgery. Obesity (Silver Spring) 21(Suppl 1):S1–S27CrossRef
10.
go back to reference Stein PD, Matta F (2013) Pulmonary embolism and deep venous thrombosis following bariatric surgery. Obes Surg 23(5):663–668PubMedCrossRef Stein PD, Matta F (2013) Pulmonary embolism and deep venous thrombosis following bariatric surgery. Obes Surg 23(5):663–668PubMedCrossRef
11.
go back to reference Winegar DA, Sherif B, Pate V, DeMaria EJ (2011) Venous thromboembolism after bariatric surgery performed by bariatric surgery center of excellence participants: analysis of the bariatric outcomes longitudinal database. Surg Obes Relat Dis 7(2):181–188PubMedCrossRef Winegar DA, Sherif B, Pate V, DeMaria EJ (2011) Venous thromboembolism after bariatric surgery performed by bariatric surgery center of excellence participants: analysis of the bariatric outcomes longitudinal database. Surg Obes Relat Dis 7(2):181–188PubMedCrossRef
12.
go back to reference Birkmeyer NJ, Share D, Baser O et al (2010) Preoperative placement of inferior vena cava filters and outcomes after gastric bypass surgery. Ann Surg 252(2):313–318PubMedCrossRef Birkmeyer NJ, Share D, Baser O et al (2010) Preoperative placement of inferior vena cava filters and outcomes after gastric bypass surgery. Ann Surg 252(2):313–318PubMedCrossRef
Metadata
Title
Thromboembolic events in bariatric surgery: a large multi-institutional referral center experience
Authors
Mohammad H. Jamal
Ricard Corcelles
Hideharu Shimizu
Mathew Kroh
Fernando M. Safdie
Raul Rosenthal
Stacy A. Brethauer
Philip R. Schauer
Publication date
01-02-2015
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 2/2015
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-014-3678-4

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