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Surgical Endoscopy

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01-06-2013 | Review

Venous thromboembolism after laparoscopic cholecystectomy: clinical burden and prevention

Authors: Fabio Rondelli, Giorgia Manina, Giancarlo Agnelli, Cecilia Becattini

Published in: Surgical Endoscopy | Issue 6/2013

Abstract

Background

The clinical benefit of prophylaxis for venous thromboembolism (VTE) in laparoscopic cholecystectomy is unclear. This study aimed to assess the clinical burden of VTE and the efficacy and safety of antithrombotic prophylaxis during laparoscopic cholecystectomy.

Methods

Data sources and study selection studies were searched in MEDLINE and Embase using the terms “cholecystectomy and venous thrombosis” and “cholecystectomy and venous thromboembolism.” Studies were considered for a systematic review and a metaanalysis if they reported on the methods of antithrombotic prophylaxis and on the incidence of objectively confirmed VTE in patients who had undergone laparoscopic cholecystectomy. Overall, 15 studies of patients who had undergone laparoscopic cholecystectomy were included in the systematic review.

Results

The incidence of VTE was lower after laparoscopic cholecystectomy than after open cholecystectomy [odds ratio (OR), 0.47; 95 % confidence interval (CI), 0.40–0.56]. No statistically significant reduction in VTE was observed in patients receiving heparin prophylaxis after laparoscopic cholecystectomy (OR, 0.86; 95 % CI, 0.12–5.82).

Conclusions

The rate of VTE after laparoscopic cholecystectomy seems to be relatively low. The clinical benefit of heparin prophylaxis for patients undergoing laparoscopic cholecystectomy remains unclear.

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Title: Venous thromboembolism after laparoscopic cholecystectomy: clinical burden and prevention
Authors: Fabio Rondelli
Giorgia Manina
Giancarlo Agnelli
Cecilia Becattini
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 6/2013
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-012-2717-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Venous thromboembolism after laparoscopic cholecystectomy: clinical burden and prevention

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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