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Surgical Endoscopy

Published in:

01-03-2010

Clinical outcomes of endoscopic submucosal dissection for undifferentiated early gastric cancer

Authors: Hae Yeon Kang, Sang Gyun Kim, Joo Sung Kim, Hyun Chae Jung, In Sung Song

Published in: Surgical Endoscopy | Issue 3/2010

Abstract

Background

Early gastric cancer (EGC) with undifferentiated histology has not been generally accepted as an indication for endoscopic treatment. This study was designed to evaluate the outcomes and clinicopathological factors associated with the complete resection of undifferentiated EGC using endoscopic submucosal dissection (ESD).

Methods

A retrospective analysis of prospectively collected data was performed on consecutive patients who underwent ESD. Among the 456 EGCs treated using ESD at the Seoul National University Hospital, Seoul, Korea, between April 2005 and June 2008, 60 lesions (13.2%) were diagnosed as undifferentiated gastric cancer (poorly differentiated adenocarcinoma or signet ring cell carcinoma).

Results

En bloc resection was performed in all lesions without significant complications. The size discrepancy between the pretreatment endoscopy and the resected specimen was significantly higher in undifferentiated EGCs than differentiated EGCs (p = 0.002). The complete resection rate was significantly lower for undifferentiated EGC (55%) cases than differentiated EGC cases (84.1%; p < 0.001). Independent risk factors for incomplete resection of undifferentiated EGC included tumor size >20 mm, submucosal invasion, and presence of ulceration. During a mean observation time of 16 months, no recurrence developed in any of the patients with undifferentiated EGCs thought to be completely resected by ESD.

Conclusions

ESD might be considered an alternative treatment modality in carefully selected cases of undifferentiated EGC.

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Title: Clinical outcomes of endoscopic submucosal dissection for undifferentiated early gastric cancer
Authors: Hae Yeon Kang
Sang Gyun Kim
Joo Sung Kim
Hyun Chae Jung
In Sung Song
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 3/2010
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-009-0614-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical outcomes of endoscopic submucosal dissection for undifferentiated early gastric cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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