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Surgical Endoscopy

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01-02-2008

A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy

Authors: G. Lezoche, M. Baldarelli, Mario, A. M. Paganini, A. De Sanctis, S. Bartolacci, E. Lezoche

Published in: Surgical Endoscopy | Issue 2/2008

Abstract

Background

This study aimed to compare the oncologic results for local excision via transanal endoscopic microsurgery (TEM) and those for laparoscopic resection (LR) via total mesorectal excision in the treatment of T₂ N₀, G_1-2rectal cancer after neoadjuvant therapy with both treatments, incorporating a 5-year minimum follow-up period.

Methods

The study enrolled 70 patients whose malignancy was staged at admission as T₂ N₀, G_1-2rectal cancer located within 6 cm of the anal verge with a tumor diameter less than 3 cm. Of these patients, 35 were randomized to TEM and 35 to LR. The patients in both groups previously had undergone high-dose radiotherapy (5,040 cGy in 28 fractions over 5 weeks) combined with continuous infusion of 5-flurouracil (200 mg/m²/day).

Results

The median follow-up period was 84 months (range, 72–96 months). Two local recurrences (5.7%) were observed after TEM and 1 (2.8%) after LR. Distant metastases (2.8%) occurred in one case each after TEM and LR. The probability of survival for rectal cancer was 94% for TEM and 94% for LR.

Conclusions

The study shows similar results between the two treatments in terms of local recurrences, distant metastases, and probability of survival for rectal cancer.

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Title: A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy
Authors: G. Lezoche
M. Baldarelli
Mario
A. M. Paganini
A. De Sanctis
S. Bartolacci
E. Lezoche
Publication date: 01-02-2008
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 2/2008
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-007-9596-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A prospective randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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