Top

Surgical Endoscopy

Published in:

01-01-2005 | Original article

Open surgery induces a dramatic decrease in circulating intact IGFBP-3 in patients with colorectal cancer not seen with laparoscopic surgery

Authors: I. Kirman, V. Cekic, N. Poltoratskaia, P. Sylla, S. Jain, K. A. Forde, R. L. Whelan

Published in: Surgical Endoscopy | Issue 1/2005

Abstract

Background

As shown earlier by the authors via Western blot analysis, open (OS) but not laparoscopic surgery (LS) induces a qualitative decrease in plasma insulin-like growth factor–binding protein 3 (IGFBP-3) levels on postoperative day 1 (POD 1). Intact IGFBP-3 has tumor suppressive effects, but its degradation products do not. Enzyme linked immunoassay (ELISA) inevitably measures both. In this study, using a novel combined Western blot and ELISA analysis method, precise plasma levels of intact IGFBP-3 on POD2 after open and closed colorectal cancer resection (stage I–III) were determined.

Methods

This study included 15 OS patients with a mean incision length of 26.7 ± 15.5 cm and 16 LS patients with a mean incision length of 5.3 ± 3.1 cm. Intact IGFBP-3 levels were determined via ELISA and Western blot analysis in plasma collected preoperatively and postoperatively.

Results

In the OS patients, the mean preoperative concentration of intact 43–45 kDa IGFBP-3 protein was 1920 ± 1430 ng/ml. It decreased dramatically on POD2 to 355 ± 545 ng/ml (p < 0.005). In the LS group, no significant difference was noted between the preoperative level (1305 ± 807 ng/ml) and the POD2 level (922 + 714 ng/ml).

Conclusions

Open cancer resection, unlike its minimally invasive alternative, induces a dramatic decrease in concentration of intact IGFBP-3, which may have important implications with regard to colon cancer recurrence.

Baxter, RC, Martin, JL, Tyler, MI, Howden, MR 1986Growth hormone–dependent insulin-like growth factor (IGF) binding protein from human plasma differs from other human IGF binding proteinsBiochem Biophys Res Commun13912561261PubMed

Booth, BA, Boes, M, Bar, RS 1996IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragmentsAm J Physiol271E465E470PubMed

Booth, BA, Boes, M, Dake, BL, Knudtson, KL, Bar, RS 2002IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysisAm J Physiol Endocrinol Metab282E52E58

Boyle, BJ, Zhao, XY, Cohen, P, Feldman, D 2001Insulin-like growth factor binding protein-3 mediates 1 alpha, 25dihydroxyvitamin d(3) growth inhibition in the LNCaP prostate cancer cell line through p21/WAF1J Urol16513191324CrossRefPubMed

Cubbage, ML, Suwanichkul, A, Powell, DR 1990Insulin-like growth factor binding protein-3: organization of the human chromosomal gene and demonstration of promoter activityJ Biol Chem2651264212649PubMed

Benedetti, F, Meazza, C, Oliveri, M, Pignatti, P, Vivarelli, M, Alonzi, T, Fattori, E, Garrone, S, Barreca, A, Martini, A 2001Effect of IL-6 on IGF-binding protein-3: a study in IL-6 transgenic mice and in patients with systemic juvenile idiopathic arthritisEndocrinology14248184826CrossRefPubMed

Fowlkes, JL, Enghild, JJ, Suzuki, K, Nagase, H 1994Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast culturesJ Biol Chem2692574225746PubMed

Gill, ZP, Perks, CM, Newcomb, PV, Holly, JM 1997Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent mannerJ Biol Chem2722560225607CrossRefPubMed

Gronbek, H, Thogersen, T, Frystyk, J, Vilstrup, H, Flyvbjerg, A, Dahlerup, JF 2002Low free and total insulin-like growth factor 1 (IGF-I) and IGF-binding protein-3 levels in chronic inflammatory bowel disease: partial normalization during prednisolone treatmentAm J Gastroenterol97673678PubMed

10.

Hong, J, Zhang, G, Dong, F, Rechler, MM 2002Insulin-like growth factor (IGF)-binding protein-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cellsJ Biol Chem2771048910497CrossRefPubMed

11.

Kirman, I, Cekic, V, Poltaratskaia, N, Asi, Z, Bessler, M, Huang, EH, Forde, KA, Whelan, RL 2002Plasma from patients undergoing major open surgery stimulates in vitro, tumor growth: lower insulin-like growth factor-binding protein-3 levels may, in part, account for this changeSurgery132186192CrossRefPubMed

12.

Kirman, I, Poltaratskaia, N, Cekic, V, Forde, K, Ansari, P, Boulay, C, Whelan, RL 2004Depletion of circulating insulin-like growth factor-binding protein-3 following open surgery is associated with high IL-6 levelsDis Colon Rectum47911917CrossRefPubMed

13.

Lee, HY, Chun, KH, Liu, B, Wiehle, SA, Cristiano, RJ, Hong, WK, Cohen, P, Kurie, JM 2002Insulin-like growth factor-binding protein-3 inhibits the growth of non–Small cell lung cancerCancer Res6235303537PubMed

14.

Li, L, Yu, H, Schumacher, F, Casey, G, Witte, JS 2003Relation of serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 to risk of prostate cancer (United States)Cancer Causes Control14721726CrossRefPubMed

15.

Ma, J, Pollak, MN, Giovannucci, E, Chan, JM, Tao, Y, Hennekens, CH, Stampfer, MJ 1999Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF-I) and IGF-binding protein-3J Natl Cancer Inst91620625

16.

Manousos, O, Souglakos, J, Bosetti, C, Tzonou, A, Chatzidakis, V, Trichopoulos, D, Adami, HO, Mantzoros, C 1999IGF-I and IGF-II in relation to colorectal cancerInt J Cancer831517CrossRefPubMed

17.

Martin, JL, Baxter, RC 1986Insulin-like growth factor-binding protein from human plasma: Purification and characterizationJ Biol Chem26187548760PubMed

18.

Matsuyama, A, Sakai, N, Ishigami, M, Hiraoka, H, Kashine, S, Hirata, A, Nakamura, T, Yamashita, S, Matsuzawa, Y 2003Matrix metalloproteinases as novel disease markers in Takayasu arteritisCirculation10814691473

19.

Miyamoto, S, Yano, K, Sugimoto, S, Ishii, G, Hasebe, T, Endoh, Y, Kodama, K, Goya, M, Chiba, T, Ochiai, A 2004Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor-binding protein-3Cancer Res64665671PubMed

20.

Renehan, AG, Painter, JE, Atkin, WS, Potten, CS, Shalet, SM, O’Dwyer, ST 2001High-risk colorectal adenomas and serum insulin-like growth factorsBr J Surg88107113

21.

Renehan, AG, Painter, JE, O’Halloran, D, Atkin, WS, Potten, CS, O’Dwyer, ST, Shalet, SM 2000Circulating insulin-like growth factor 2 and colorectal adenomasJ Clin Endocrinol Metab8534023408CrossRefPubMed

22.

Tchetverikov, I, Lard, LR, DeGroot, J, Verzijl, N, TeKoppele, JM, Breedveld, FC, Huizinga, TW, Hanemaaijer, R 2003Matrix metalloproteinases-3, 8, 9 as markers of disease activity and joint damage progression in early rheumatoid arthritisAnn Rheum Dis6210941099CrossRefPubMed

23.

Valentinis, B, Bhala, A, DeAngelis, T, Baserga, R, Cohen, P 1995The human insulin-like growth factor (IGF)-binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor geneMol Endocrinol9361367CrossRefPubMed

24.

Zhao, H, Grossman, HB, Spitz, MR, Lerner, SP, Zhang, K, Wu, X 2003Plasma levels of insulin-like growth factor-1 and binding protein-3, and their association with bladder cancer riskJ Urol169714717CrossRefPubMed

Title: Open surgery induces a dramatic decrease in circulating intact IGFBP-3 in patients with colorectal cancer not seen with laparoscopic surgery
Authors: I. Kirman
V. Cekic
N. Poltoratskaia
P. Sylla
S. Jain
K. A. Forde
R. L. Whelan
Publication date: 01-01-2005
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 1/2005
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-004-8906-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Open surgery induces a dramatic decrease in circulating intact IGFBP-3 in patients with colorectal cancer not seen with laparoscopic surgery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2005

The role of hand-assisted laparoscopic distal gastrectomy for distal gastric cancer

The effect of timing of pneumoperitoneum on the inflammatory response

Influence of different gases used for laparoscopy (helium, carbon dioxide, room air, and xenon) on tumor volume, histomorphology, and leukocyte–tumor–endothelium interaction in intravital microscopy

Advantages and limits of robot-assisted laparoscopic surgery: preliminary experience

Power spectral analysis of heart rate variability during helium pneumoperitoneum: The mechanism of increased cardiac sympathetic activity and its clinical significance

What can the operator actually feel when performing a laparoscopy?