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Journal of Cancer Research and Clinical Oncology

Published in:

01-08-2009 | Original Paper

Plasma malondialdehyde levels and CXCR4 expression in peripheral blood cells of breast cancer patients

Authors: Juliana Laino do Val Carneiro, Suzana Lucy Nixdorf, Mário Sérgio Mantovani, Ana Cristina da Silva do Amaral Herrera, Mateus Nobrega Aoki, Marla Karine Amarante, Bruno Alberto Fabris, Maria Helena Pelegrinelli Fungaro, Maria Angelica Ehara Watanabe

Published in: Journal of Cancer Research and Clinical Oncology | Issue 8/2009

Abstract

Introduction

Breast cancer is one of the most common neoplasms in women and is a leading cause of cancer related deaths worldwide. Chemokines and their receptors are involved in the control of lymphocyte traffic, a critical component of systemic immunity. CXCR4 mRNA could be involved in the development of variety of diseases. Lipid peroxidation, the result of nonenzymatic autooxidation of polyunsaturated fatty acids, presents numerous harmful effects on biological systems and has been implicated in diseases like cancer. This study examined CXCR4 mRNA expression in peripheral blood cells and malondialdehyde (MDA) in plasma from blood donors and breast cancer patients.

Materials and methods

CXCR4 expression in peripheral blood cells from 59 breast cancer patients and 76 healthy blood donors was analyzed by real-time PCR. Plasma MDA was analyzed using high-performance liquid chromatography (HPLC).

Conclusion

In all stages, MDA levels in total breast cancer patients (1.41 ± 0.11) were significantly higher (P < 0.01) than those in healthy subjects (0.34 ± 0.03). No statistically significant difference occurred between CXCR4 expression in peripheral blood cells from breast cancer patients (1.69 ± 1.05) and the normal healthy control group (1.8 ± 0.65). However, stage II samples differed statistically (4.3 ± 1.72) from control, total cancer patients and stages I, III and IV samples.

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Title: Plasma malondialdehyde levels and CXCR4 expression in peripheral blood cells of breast cancer patients
Authors: Juliana Laino do Val Carneiro
Suzana Lucy Nixdorf
Mário Sérgio Mantovani
Ana Cristina da Silva do Amaral Herrera
Mateus Nobrega Aoki
Marla Karine Amarante
Bruno Alberto Fabris
Maria Helena Pelegrinelli Fungaro
Maria Angelica Ehara Watanabe
Publication date: 01-08-2009
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 8/2009
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-008-0535-7

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Abstract

Introduction

Materials and methods

Conclusion

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