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01-08-2013 | Original Article

Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants

Authors: Erman Atas, Ferhan Karademır, Atilla Ersen, Cihan Meral, Secil Aydınoz, Selami Suleymanoglu, Mustafa Gultepe, İsmail Gocmen

Published in: European Journal of Pediatrics | Issue 8/2013

Abstract

The daily supplementation of vitamin D is mandatory for infants. However, there are still conflicting opinions about the exact daily dose. Thus, we aimed to evaluate a daily supplementation dose of 200 IU is sufficient and compared the supplementation doses of 200 and 400 IU per day. One hundred and sixty-nine infants were randomly assigned to two groups (group1, 200 IU/day; group 2, 400 IU/day) and there were 75 infants in group 1 and 64 were in group 2 with a total number of 139. The median levels of 25-hydroxyvitamin D3 were significantly increased in group 2 at the age of 4 months (group 1, 39.60 mcg/L; group 2, 56.55 mcg/L; p < 0.0001). We clearly demonstrated that at the age of 4 months, none of the infants on the group 2 had a serum level of 25-hydroxyvitamin D3 less than 30 mcg/L. However, 21.3 % of the infants in group 1 had a level below 30 mcg/L. Thus, in order to avoid vitamin D deficiency and rickets, we recommend supplementation dose of vitamin D at 400 IU/day as a safe and effective dose.

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Title: Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants
Authors: Erman Atas
Ferhan Karademır
Atilla Ersen
Cihan Meral
Secil Aydınoz
Selami Suleymanoglu
Mustafa Gultepe
İsmail Gocmen
Publication date: 01-08-2013
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 8/2013
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-013-1997-4

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Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants

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