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European Journal of Pediatrics
Published in: European Journal of Pediatrics 3/2011

01-03-2011 | Original Paper

The effect of vitamin A on renal damage following acute pyelonephritis in children

Authors: Parviz Ayazi, Seyed Alireza Moshiri, Abolfazl Mahyar, Mona Moradi

Published in: European Journal of Pediatrics | Issue 3/2011

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Abstract

Animal studies suggest that administration of vitamin A to rats with experimental urinary tract infection decreases the frequency of renal scars (Kavukçu et al., BJU Int 83(9):1055–1059, 1999). The aim of this study was to determine the effect of vitamin A on the rate of permanent renal damage in children with acute pyelonephritis. Fifty children, median age of 24 months (range 2–144), with first-time pyelonephritis verified by an uptake defect on acute dimercaptosuccinic acid (DMSA) scan were included in the study and randomly allocated to the case or control groups. All were given intravenous ceftriaxone for 10 days followed by oral cephalexin for 3 months. Cases in addition were given a single intramuscular dose of vitamin A, 25,000 U for infants below 1 year of age and 50,000 U for older children. At the repeat DMSA scan after 3 months, five of 25 cases (20%) and 17 of 25 controls (68%) had abnormal findings (p = 0.001). In conclusion, administration of vitamin A was associated with a significantly lower rate of permanent renal damage.
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Metadata
Title
The effect of vitamin A on renal damage following acute pyelonephritis in children
Authors
Parviz Ayazi
Seyed Alireza Moshiri
Abolfazl Mahyar
Mona Moradi
Publication date
01-03-2011
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 3/2011
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-010-1297-1

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