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Open Access 01-03-2011 | Short Report

Effect of cyclosporin A on proteinuria in the course of glomerulopathy associated with WT1 mutations

Authors: Anna Maria Wasilewska, Elżbieta Kuroczycka-Saniutycz, Walentyna Zoch-Zwierz

Published in: European Journal of Pediatrics | Issue 3/2011

Abstract

Denys–Drash syndrome (DDS) is characterized by progressive glomerulopathy caused by diffuse mesangial sclerosis (DMS), genitourinary defects, and a higher risk of developing Wilms’ tumor. It is commonly assumed that the DMS is unresponsive to any medications. In this report, we present a patient with Denys–Drash syndrome, in whom the cyclosporine A (CsA) was found to induce total remission. This observation and observations of other authors confirm that in genetic forms of nephrotic syndrome, the proteinuric effect of CsA may be due to a non-immunologic mechanism. We confirm the beneficial effect of CsA treatment in DDS; however, the potential nephrotoxicity of this drug will probably not allow long-term use.

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Title: Effect of cyclosporin A on proteinuria in the course of glomerulopathy associated with WT1 mutations
Authors: Anna Maria Wasilewska
Elżbieta Kuroczycka-Saniutycz
Walentyna Zoch-Zwierz
Publication date: 01-03-2011
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 3/2011
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-010-1278-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of cyclosporin A on proteinuria in the course of glomerulopathy associated with WT1 mutations

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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