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European Journal of Pediatrics

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Open Access 01-12-2010 | Review

Clinical practice

The care of children with Down syndrome

Authors: Michel E. Weijerman, J. Peter de Winter

Published in: European Journal of Pediatrics | Issue 12/2010

Abstract

Down syndrome (DS) is one of the most common chromosomal abnormalities. Because of medical advances and improvements in overall medical care, the median survival of individuals with DS has increased considerably. This longer life expectancy requires giving the necessary care to the individual with DS over their total longer lifespan. DS medical guidelines are designed for the optimal care of the child in whom a diagnosis of DS has been confirmed. We present an overview of the most important issues related to children with DS based on the most relevant literature currently available.

Bertrand P, Navarro H, Caussade S et al (2003) Airway anomalies in children with Down syndrome: endoscopic findings. Ped Pulm 36:137–141CrossRef

Biko DM, Schwartz M, Anupindi SA, Altes TA (2008) Subpleural lung cysts in Down syndrome: prevalence and association with coexisting diagnoses. Pediatr Radiol 38:280–284CrossRefPubMed

Bloemers BLP, van Furth AM, Weijerman ME et al (2007) Down syndrome: a novel risk factor for respiratory syncytial virus bronchiolitis—a prospective birth-cohort study. Pediatrics 120:e1076–e1081CrossRefPubMed

Bloemers BLP, van Furth AM, Weijerman ME et al (2010) High incidence of recurrent wheeze in children with Down syndrome with and without previous respiratory syncytial virus lower respiratory tract infection. Pediatr Infect Dis J 29:39–42CrossRefPubMed

Caird MS, Wills BP, Dormans JP (2006) Down syndrome in children: the role of the orthopaedic surgeon. J Am Acad Orthop Surg 14:610–619PubMed

Collins VR, Muggli EE, Riley M et al (2008) Is Down syndrome a disappearing birth defect? J Pediatr 152:20–24CrossRefPubMed

Cremers MJ, van der Twee I, Boersma B et al (1996) Growth curves of Dutch children with Down syndrome. J Intellect Disabil Res 40:412–420CrossRefPubMed

Cunnif C, Frias JL, Kaye C et al (2001) Health supervision for children with Down syndrome, American Academy of Pediatrics. Pediatrics 107:442–449CrossRef

Freeman SB, Torfs CA, Romitti MH et al (2009) Congenital gastrointestinal defects in Down syndrome: a report from the Atlanta and National Down Syndrome Projects. Clin Genet 75:180–184CrossRefPubMed

10.

Gibson PA, Newton RW, Selby K et al (2005) Longitudinal study of thyroid function in Down’s syndrome in the first two decades. Arch Dis Child 09:575–578

11.

Guidelines for basic essential medical surveillance. The Down’s syndrome medical interest group UK and Ireland. Available at: http://www.dsmig.org.uk/publications/guidelines.html Accessed 29 Jan 2010

12.

Hankinson TC, Anderson RC (2010) Craniovertebral junction abnormalities in Down syndrome. Neurosurgery 66:A32–A38CrossRef

13.

Hilton JM, Fitzgerald DA, Cooper DM (1999) Respiratory morbidity of hospitalized children with Trisomy 21. Paediatr Child Health 35:383–386CrossRef

14.

Irving C, Basu A, Richmond S et al (2008) Twenty-year trends in prevalence and survival of Down syndrome. Eur J Hum Genet 16:1336–1340CrossRefPubMed

15.

Kishnani PS, Crissman BG (2006) Special issue: current perspectives on Down syndrome: selected medical and social issues. Am J Med Genet C Semin Med Genet 142C:127–205CrossRefPubMed

16.

Kupferman JC, Druschel CM, Kupchik GS (2009) Increased prevalence of renal urinary tract anomalies in children with Down syndrome. Pediatrics 124:e615–e621CrossRefPubMed

17.

Mannan SE, Ejaz Y, Hossain J (2009) Prevalence of positive skin prick test results in children with Down syndrome: a case control study. Ann Allergy Asthma Immunol 102:2005–2009CrossRef

18.

Madan V, Williams J, Lear JT (2006) Dermatological manifestations of Down’s syndrome. Clin Exp Dermatol 31(5):623–629CrossRefPubMed

19.

Muggli EE, Collins VR, Marraffa C (2009) Going down a different road: first support and information needs of families with a baby with Down syndrome. MJA 190:58–61PubMed

20.

Rex AP, Preus M (1982) A diagnostic index for Down syndrome. J Pediatr 6:903–906

21.

Roizen NJ, Patterson D (2003) Down’s syndrome. Lancet 361:1281–1289CrossRefPubMed

22.

Roofthooft MT, van Meer H, Rietman WG et al (2008) Down syndrome and aberrant right subclavian artery. Eur J Pediatr 167:1033–1036CrossRefPubMed

23.

Schepis C, Barone C, Siragusa M et al (2002) An updated survey on skin conditions in Down syndrome. Dermatology 20:234–238CrossRef

24.

Shin M, Besser LM, Kucik JE et al (2009) Prevalence of Down Syndrome among children and adolescents in 10 regions of the United States. Pediatrics 124:1565–1571CrossRefPubMed

25.

Shott SR, Amin R, Chini B et al (2006) Obstructive sleep apnea should all children with Down syndrome be tested? Arch Otolaryngol Head Neck Surg 132:432–436CrossRefPubMed

26.

Skotko BG, Capone GT, Kishnani S (2009) Postnatal diagnosis of Down syndrome: synthesis of the evidence on how best to deliver the news. Pediatrics 124:e751–e758CrossRefPubMed

27.

Stephen E, Dickson J, Kindley AD et al (2007) Surveillance of vision and ocular disorders in children with Down syndrome. Dev Med Child Neurol 49:513–515CrossRefPubMed

28.

Unachak K, Tanpaiboon P, Yupada Pongprot Y et al (2008) Thyroid functions in children with Down’s syndrome. J Med Assoc Thai 91:56–61PubMed

29.

van Trotsenburg ASP, Vulsma T, van Rozenburg-Marres SLR et al (2005) The Effect of thyroxine treatment started in the neonatal period on developmentand growth of two-year-old Down syndrome children: a randomized clinical trial. J Clin Endocrinol Metab 90:3304–3311CrossRefPubMed

30.

van Wouwe JP, Siderius EJ, Borstlap R et al (2001) Optimal medical care for children with Down syndrome and their parents. Ned Tijdschr Geneeskd 145:1617–1621PubMed

31.

Vis JC, Duffels MGJ, Winter MM et al (2009) Down syndrome: a cardiovascular perspective. J Intellect Disabil Res 53:419–425CrossRefPubMed

32.

Volman MJ, Visser JJ, Lensvelt-Mulders GJ (2007) Functional status in 5 to 7-year-old children with Down syndrome in relation to motor ability and performance mental ability. Disabil Rehabil 29:25–31CrossRefPubMed

33.

Weijerman ME, van Furth AM, Vonk Noordegraaf A et al (2008) Prevalence, neonatal characteristics and first-year mortality of Down syndrome: a national study. J Pediatrics 152:15–19CrossRef

34.

Weijerman ME, van Furth AM, Mooren MD et al (2010) Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome. Eur J Pediatr. doi:10.1007/s00431-010-1200-0

35.

Wiseman FK, Alford KA, Tybulewicz VL et al (2009) Down syndrome—recent progress and future prospects. Hum Mol Genet 18(R1):75–83CrossRef

36.

Wong V, Ho D (1997) Ocular abnormalities in Down syndrome: an analysis of 140 Chinese children. Pediatr Neurol 16:311–314CrossRefPubMed

37.

Wouters J, Weijerman ME, van Furth AM et al (2009) Prospective HLA, EMA, and TGA testing celiac disease in children with Down syndrome. J Pediatrics 154:239–242CrossRef

38.

Yang Q, Rasmussen SA, Friedma JM (2002) Mortality associated with Down’s syndrome in the USA from 1983 to 1997: a population-based study. Lancet 359:1019–1025CrossRefPubMed

39.

Zwaan MC, Reinhardt DR, Hizler J, Vyas P (2008) Acute leukemias in children with Down syndrome. Pediatr Clin North Am 55:53–70CrossRefPubMed

Title: Clinical practice
The care of children with Down syndrome
Authors: Michel E. Weijerman
J. Peter de Winter
Publication date: 01-12-2010
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 12/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-010-1253-0

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Clinical practice

The care of children with Down syndrome

Abstract

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Abstract

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