Published in:
01-02-2008 | Short Report
Severe mycobacterial infections in two pairs of Chinese siblings with interleukin-12 receptor β1 deficiency
Authors:
P. P. W. Lee, L. P. Jiang, X. C. Wang, K. W. Chan, W. W. Tu, Y. L. Lau
Published in:
European Journal of Pediatrics
|
Issue 2/2008
Login to get access
Excerpt
IL-12β1 deficiency is characterized by selective susceptibility to weakly virulent organisms, including Mycobacterium bovis BCG, non-tuberculous environmental mycobacteria and non-typhoidal salmonellosis. We report here on three cases of Bacille Calmette-Gurin (BCG) disease and one case of disseminated tuberculosis (TB) in two pairs of Chinese siblings with IL-12Rβ1 deficiency. …