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European Journal of Pediatrics
Published in: European Journal of Pediatrics 8/2007

01-08-2007 | Original Paper

Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus

Authors: Yun-Mi Song, Joohon Sung, Soonha Yang, Yon Ho Choe, Yun Sil Chang, Won Soon Park

Published in: European Journal of Pediatrics | Issue 8/2007

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Abstract

In spite of adequate immunoprophylaxis, perinatal transmission of hepatitis B virus (HBV) has not been completely eliminated. This study evaluated the factors associated with the failure of HBV immunoprophylaxis. The study participants were 144 children who were born to HBsAg-seropositive mothers of known HBeAg status and they had received HB immune globulin and HB vaccine within 24 hours after birth followed by two further administrations of HB vaccine as recommended. Seventeen of the children (11.8%) suffered immunoprophylaxis failure, defined by HBsAg-seropositivity. The rate of HBV immunoprophylaxis failure was 12%, 0%, 21%, 0%, and 27% among the children born to HBsAg-seropositive, HBeAg-seronegative, HBeAg-seropositive, undetectable HBV DNA, and detectable HBV DNA mothers, respectively. The failure of HBV immunoprophylaxis was significantly associated with maternal HBeAg-seropositivity and HBV DNA seropositivity. To identify those children at high risk of HBV immunoprophylaxis failure, maternal HBeAg and HBV DNA need to be assessed prior to childbirth.
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Metadata
Title
Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus
Authors
Yun-Mi Song
Joohon Sung
Soonha Yang
Yon Ho Choe
Yun Sil Chang
Won Soon Park
Publication date
01-08-2007
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 8/2007
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-006-0327-5

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