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01-07-2003 | Original Paper

Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide

Authors: Elke De Wachter, Jesse Vanbesien, Iris De Schutter, Anne Malfroot, Jean De Schepper

Published in: European Journal of Pediatrics | Issue 7-8/2003

Abstract

A 4-year-old boy with cystic fibrosis developed hypertension, rapid weight gain and a moon face 2 weeks after starting a combined treatment of oral itraconazole and inhaled budesonide for a suspected allergic bronchopulmonary aspergillosis. Adrenal suppression was documented and found to persist 3 months after stopping this combined treatment. Conclusion:to the best of our knowledge, this is the first time that an iatrogenic Cushing syndrome in a young child with cystic fibrosis after such combined treatment is reported. The inhibition of cytochrome P4503A by intraconazole and a higher glucocorticoid tissue sensitivity is suggested as the underlying mechanism.

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Title: Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide
Authors: Elke De Wachter
Jesse Vanbesien
Iris De Schutter
Anne Malfroot
Jean De Schepper
Publication date: 01-07-2003
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 7-8/2003
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-003-1233-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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