Skip to main content
Top
Published in: European Journal of Pediatrics 7-8/2003

01-07-2003 | Research Letter

Stool interleukin 1β and interleukin 1 receptor antagonist concentrations in children with active ulcerative colitis and during recovery

Authors: Andrzej Wedrychowicz, Janina Stopyrowa, Krzysztof Fyderek, Witold Miezynski

Published in: European Journal of Pediatrics | Issue 7-8/2003

Login to get access

Excerpt

Interleukin 1β (IL-1β) and interleukin 1 receptor antagonist (IL-1ra) contribute to the development of ulcerative colitis (UC) and concentrations of these interleukins in serum and colonic mucosa are increased in children with UC [2, 3]. Nevertheless, except for one study on stool interleukin detection in adult UC patients [7], there are few data on stool IL-1β and IL-1ra concentrations and IL-1ra/IL-1β ratios in children with UC. We report the results of our study on measurement of IL-1β and IL-1ra concentrations in stools of children with active UC and during recovery and assessment of their correlations with UC activity. …
Literature
1.
go back to reference Cuvelier C, Barbatis C, Mielants H, De Vos M, Roels H, Veys A (1987) Histopathology of intestinal inflammation related to reactive arthritis. Gut 28: 394–401CrossRefPubMedPubMedCentral Cuvelier C, Barbatis C, Mielants H, De Vos M, Roels H, Veys A (1987) Histopathology of intestinal inflammation related to reactive arthritis. Gut 28: 394–401CrossRefPubMedPubMedCentral
2.
go back to reference Isaacs KL, Sartor RB, Haskill S (1992) Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology 103: 1587–1595CrossRefPubMed Isaacs KL, Sartor RB, Haskill S (1992) Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology 103: 1587–1595CrossRefPubMed
3.
go back to reference Mahida YR, Wu K, Jewell DP (1989) Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease. Gut 30: 835–838CrossRefPubMedPubMedCentral Mahida YR, Wu K, Jewell DP (1989) Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn's disease. Gut 30: 835–838CrossRefPubMedPubMedCentral
4.
go back to reference Nicholls S, Stephens S, Braegger CP, Walker-Smith JA, MacDonald TT (1993) Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea. J Clin Pathol 46: 757–760CrossRefPubMedPubMedCentral Nicholls S, Stephens S, Braegger CP, Walker-Smith JA, MacDonald TT (1993) Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea. J Clin Pathol 46: 757–760CrossRefPubMedPubMedCentral
5.
go back to reference Roth JLA (1976) Ulcerative colitis. In: Bockus HL (ed) Gastroenterology. Saunders, Philadelphia, pp 645–749 Roth JLA (1976) Ulcerative colitis. In: Bockus HL (ed) Gastroenterology. Saunders, Philadelphia, pp 645–749
6.
go back to reference Ryzko J, Woynarowski M (1995) Application of score index in determination of Crohn's disease and ulcerative colitis in children. Pediatr Pol 70: 585–589PubMed Ryzko J, Woynarowski M (1995) Application of score index in determination of Crohn's disease and ulcerative colitis in children. Pediatr Pol 70: 585–589PubMed
7.
go back to reference Saiki T, Mitsuyama K, Toyonaga A, Ishida H, Tanikawa K (1998) Detection of pro- and anti-inflammatory cytokines in stools of patients with inflammatory bowel disease. Scand J Gastroenterol 33: 616–622CrossRefPubMed Saiki T, Mitsuyama K, Toyonaga A, Ishida H, Tanikawa K (1998) Detection of pro- and anti-inflammatory cytokines in stools of patients with inflammatory bowel disease. Scand J Gastroenterol 33: 616–622CrossRefPubMed
8.
go back to reference Wedrychowicz A, Stopyrowa J, Fyderek K, Miezynski W (2000) Serum and stool interleukin 6 in active and inactive ulcerative colitis in children. Pediatria Wspolczesna 3: 165–169 Wedrychowicz A, Stopyrowa J, Fyderek K, Miezynski W (2000) Serum and stool interleukin 6 in active and inactive ulcerative colitis in children. Pediatria Wspolczesna 3: 165–169
Metadata
Title
Stool interleukin 1β and interleukin 1 receptor antagonist concentrations in children with active ulcerative colitis and during recovery
Authors
Andrzej Wedrychowicz
Janina Stopyrowa
Krzysztof Fyderek
Witold Miezynski
Publication date
01-07-2003
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 7-8/2003
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-003-1204-0

Other articles of this Issue 7-8/2003

European Journal of Pediatrics 7-8/2003 Go to the issue