Published in:
01-07-2003 | Research Letter
Stool interleukin 1β and interleukin 1 receptor antagonist concentrations in children with active ulcerative colitis and during recovery
Authors:
Andrzej Wedrychowicz, Janina Stopyrowa, Krzysztof Fyderek, Witold Miezynski
Published in:
European Journal of Pediatrics
|
Issue 7-8/2003
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Excerpt
Interleukin 1β (IL-1β) and interleukin 1 receptor antagonist (IL-1ra) contribute to the development of ulcerative colitis (UC) and concentrations of these interleukins in serum and colonic mucosa are increased in children with UC [
2,
3]. Nevertheless, except for one study on stool interleukin detection in adult UC patients [
7], there are few data on stool IL-1β and IL-1ra concentrations and IL-1ra/IL-1β ratios in children with UC. We report the results of our study on measurement of IL-1β and IL-1ra concentrations in stools of children with active UC and during recovery and assessment of their correlations with UC activity. …